Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 Biomarker disease BEFREE The most common RET fusions are CDCC6-RET and NCOA4-RET in PTC and KIF5B-RET in NSCLC. 31715421 2019
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 GeneticVariation disease BEFREE Two samples harboring RET/PTC1 and RET/PTC3 rearrangements were positive controls whereas the remaining ones were negative regarding the common PTC alterations. 30664823 2019
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 GeneticVariation disease BEFREE MATERIAL AND METHODS Four cell lines included TPC-1 (BRAFWT/WT), BCPAP (BRAFV600E/V600E), PCCL3, and PTC3-5 (RET/PTC), were grown in culture in vitro with or without suppression of NF-κB using pyrrolidine dithiocarbamate (PDTC), and cell proliferation, and cell migration were evaluated. 29117154 2017
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 Biomarker disease BEFREE Six of 27 PTCs (22%) had ret proto-oncogene (RET) fusions (RET/PTC1, n = 5; RET/PTC3, n = 1); 2 tumors measured >2 cm and diffusely involved the thyroid, and 5 had lymphatic invasion, with vascular invasion in 2. 26784937 2016
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 Biomarker disease BEFREE Stratified analysis according to RET/PTC subtype and geographical area showed that this association was restricted to the RET/PTC3 subtype (OR = 8.30, 95%CI: 4.32-15.96, P < 0.001) in the Western population. 26918339 2016
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 FusionGene disease ORPHANET Among 73 PTC patients with sufficient tissue available for FISH and multiplex qPCR, 10 cases were defined as RET/PTC positive by both assays, including eight CCDC6/RET and two NCOA4/RET fusions with relatively high RET mRNA. 25407564 2015
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 GeneticVariation disease BEFREE Our results indicate that RET/PTC3 gene rearrangements are the most prevalent form of rearrangements in PTCs of Chennai population. 24957039 2014
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 Biomarker disease BEFREE Hence, our findings highly support the use of siRNA RET/PTC3-SQ NPs as a new promising treatment for patients affected by PTC expressing RET/PTC3. 24759995 2014
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 AlteredExpression disease BEFREE Nuclear receptor coactivator 4 (NcoA4), also known as androgen receptor-associated protein 70 (ARA70), was initially discovered as a component of Ret-Fused Gene expressed in a subset of papillary thyroid carcinomas. 22562579 2012
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 GeneticVariation disease BEFREE Twenty-five PTCs (11 with BRAF(V600E), 4 with RET/PTC1, and 10 without mutation in HRAS, KRAS, NRAS, BRAF, RET/PTC1, or RET/PTC3) were analyzed using Genome-Wide Human SNP Array 6.0 which allows us to detect copy number alteration (CNA) and uniparental disomy (UPD), also referred to as copy neutral loss of heterozygosity, in a single experiment. 22558328 2012
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 Biomarker disease BEFREE Influence of RET/PTC1 and RET/PTC3 oncoproteins in radiation-induced papillary thyroid carcinomas on amounts of cytoskeletal protein species. 20839015 2011
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 GeneticVariation disease BEFREE The BRAF(V600E) was found in 84/266 (31.6%) cases, RAS mutations in 11/266 (4.1%) and RET/PTC in 55/266 (20.7%; 42/266 (15.8%) RET/PTC1 and 13/266 (4.9%) RET/PTC3). 21498916 2011
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 Biomarker disease BEFREE Gene expression in RET/PTC3 and E7 transgenic mouse thyroids: RET/PTC3 but not E7 tumors are partial and transient models of human papillary thyroid cancers. 18583418 2008
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 Biomarker disease BEFREE Human rearranged RET/PTC3 (papillary thyroid carcinoma) proto-oncogene and high-risk human papillomavirus (HPV) type 16 E7 oncogene induces in the mouse a neoplastic transformation of thyroid follicular cells. 18985036 2008
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 GeneticVariation disease BEFREE RET/PTC1 (two out of seven) and RET/PTC3 (one out of seven), which have been shown in large PTC series to comprise together more than 90% of RET/PTC types, were found in <50% of the cases investigated. 17464312 2007
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 GeneticVariation disease BEFREE To evaluate BRAF(V600E) mutation on consecutive fine-needle aspiration biopsy (FNAB) specimens in order to assess FNAB's usefulness in preoperative papillary thyroid carcinoma (PTC) diagnosis with the contemporaneous analysis of RET/PTC1 and RET/PTC3 rearrangements obtained from ex vivo thyroid nodules. 17727338 2007
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 Biomarker disease BEFREE Rearrangements of the RET protooncogene (RET/PTC1, RET/PTC2 and RET/PTC3) were detected in 7 out of 33 PTC (21%), and rearrangements of NTRK1 [Trk-T1 and Trk(TPM3)] were detected in 4 out of 33 examined samples (12%). 16483615 2006
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 Biomarker disease BEFREE RET gene rearrangements (RET/PTC1 and RET/PTC3) in papillary thyroid carcinomas from an iodine-rich country (Japan). 16015630 2005
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 GeneticVariation disease BEFREE In our study, RET/PTC1, RET/PTC2, and RET/PTC3 oncogenes were found in only 7 of 105 (7%) sporadic PTCs. 15876154 2005
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 AlteredExpression disease BEFREE Real-time quantitative RT-PCR identifies distinct c-RET, RET/PTC1 and RET/PTC3 expression patterns in papillary thyroid carcinoma. 15502856 2004
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 AlteredExpression disease BEFREE Ret/PTC-3 was detected in only follicular variant subtype (60%) and was not detected in classic PTC. 12574236 2003
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 Biomarker disease BEFREE Whereas the prevalences of RET/PTC1 and RET/PTC3 were almost equal in classic and follicular PTC, all of the TCV-positive cases expressed the RET/PTC3 rearrangement. 11786418 2002
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 Biomarker disease BEFREE The prevalence of RET/PTC activation in PTC is high and RET/PTC3 is the only type of activation identified in Hong Kong Chinese and is an important genetic event underlying the development of PTC in the population. 12457448 2002
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 Biomarker disease BEFREE Using the RT-PCR technique, we observed a RET/PTC rearrangement in the carcinomatous areas of patients of both families: PTC1 in family 1 and PTC3 in family 2 and a RET/PTC rearrangement in non-malignant thyroid tissue with LT in family 2. 11747322 2001
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4
0.400 GeneticVariation disease BEFREE More than 90% of PTC with RET rearrangement exhibit a PTC1 or PTC3 type of rearrangement with an inversion of the H4 or ELE1 gene, respectively, on chromosome 10. 11318605 2001