Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE Outcome variables were: a) liver fibrosis (Metavir score) [fibrosis stage (F0, F1, F2, F3 and F4) and advanced fibrosis and cirrhosis (F ≥ 3 and F4, respectively)]; b) non-invasive indexes [FIB-4, APRI, and their cut-offs (FIB-4 ≥ 3.25 and APRI≥1.5)]; c) inflammation-related biomarkers (leptin, HGF, NGF, sFasL, sFas, MIF, HA, Ang-2, TIMP1, MMP1 and MMP2). 30336268 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Furthermore, we detected the key factors involved in liver fibrosis in the mice, revealing significantly increased hydroxyproline concentration; elevated expression of α-smooth muscle actin (α-SMA) and fibrosis-related genes such as Collagen-1, Collagen-3, Mmp2, Mmp13, Timp1, Timp3, and Activin, upregulated Smad3 phosphorylation, and increased serum TGF-β levels. 30367152 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE In conclusion, PS-modified NLCs nanoparticles prolonged the retention time of Cur, and enhanced its bioavailability and delivery efficiency to the livers, resulting in reduced liver fibrosis and up-regulating hepatic expression of HGF and MMP-2. 29214887 2018
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE Salidroside inhibited the production of extracellular matrix (ECM) and regulated the balance between MMP2 and TIMP1 and, therefore, alleviated liver fibrosis in the two fibrosis models. 29970958 2018
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE The increased MMP-2/TIMP-2 and suppressed MMP-9/TIMP-1 ratios in IHC and in real-time polymerase chain reaction (RT-PCR) seemed to correlate with the degree of liver fibrosis. 30019784 2018
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE Consistent with the results of in vitro study, intrahepatic IFN-γ/STAT1 levels increased in relation to the severity of liver fibrosis in BA patients, and the altered balance between MMP2 and TIMP1 expressions in livers may contribute to increased deposition of extracellular matrix and fibrosis. 28304404 2017
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE The mechanism of development of liver fibrosis involves activation of Matrix metalloproteinase-2 (MMP-2) and Matrix metalloproteinase-9 (MMP-9), upregulation of HIF-1α transcriptional activity and its related factors, NF-κB and TGF-β. 27260943 2017
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease CTD_human Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis. 26396155 2016
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE In liver fibrosis in both human and mouse tissue MMP expression and activity (MMP-2, -9, -13 and -14) increased with progressive injury and localised to hepatocytes. 25076423 2014
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Resolution of liver fibrosis by isoquinoline alkaloid berberine in CCl₄-intoxicated mice is mediated by suppression of oxidative stress and upregulation of MMP-2 expression. 23734997 2013
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE These findings suggest that increased MMP-2 during the progression of liver fibrosis may be an important mechanism for inhibiting type I collagen synthesis by activated HSCs, thereby providing a protective rather than pathologic role. 20563750 2011
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease CTD_human Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression. 15763341 2005
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE We studied matrix metalloproteinase-2 (MMP-2), -7, -9 and -13 mRNA expressions in the liver tissue of early-stage biliary atresia at the time of Kasai's procedure, late-stage biliary atresia at the time of liver transplantation with advanced fibrosis and nondiseased control without liver fibrosis. 15696117 2005
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 Biomarker disease BEFREE This study verified differential expression of MMPs and TIMPs in different stages of BA, with emphasis on the role of TIMP-1, -2, and -3 as well as MMP-2, -7, and -9 transcripts in remodeling of liver tissue during the progress of BA-associated liver fibrosis. 16226986 2005
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE We examined MMP-2 and MMP-14 expression in established and resolving fibrosis to assess their role in resolution of liver fibrosis. 15482348 2004
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Intrahepatic COX-2, MMP-2, and MMP-9 overexpression is associated with progressive hepatic fibrosis in chronic HCV infection, suggesting their pathogenic role in fibrogenesis. 15479690 2004
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.400 AlteredExpression disease BEFREE Serum MMP-2 and TIMP-1 levels might be useful for estimating the degree of liver fibrosis. 9075665 1997