Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7046
Gene Symbol: TGFBR1
TGFBR1
0.350 Biomarker disease BEFREE GDNF promotes HSC activation and liver fibrosis through ALK5/Smad signalling. 31171625 2019
Entrez Id: 7046
Gene Symbol: TGFBR1
TGFBR1
0.350 AlteredExpression disease BEFREE The high level of HOTTIP downregulates miR-148a, thus to increase the level of TGFBR1 and TGFBR2 and contribute to liver fibrosis. 30562760 2018
Entrez Id: 7046
Gene Symbol: TGFBR1
TGFBR1
0.350 Biomarker disease CTD_human To shed more light on the hepatocyte-specific role of Tgf-β signaling during liver fibrosis, we generated transgenic mice expressing constitutively active Tgf-β type I receptor Alk5 under the control of albumin promoter. 28560358 2017
Entrez Id: 7046
Gene Symbol: TGFBR1
TGFBR1
0.350 GeneticVariation disease BEFREE Therefore, the aim of our study was to investigate whether genetic variation in 3' untranslated region (3'UTR) of TGF-β receptor type I (TGFBR1) gene is associated with recurrence and severity of hepatitis C and liver fibrosis following OLT in HCV-infected patients. 25502482 2014
Entrez Id: 7046
Gene Symbol: TGFBR1
TGFBR1
0.350 Biomarker disease BEFREE These data suggest that HCV NS3 protease mimics TGF-β2 and functions, at least in part, via directly binding to and activating TβRI, thereby enhancing liver fibrosis. 24263861 2013
Entrez Id: 7046
Gene Symbol: TGFBR1
TGFBR1
0.350 Biomarker disease BEFREE This ALK5 inhibitor was then tested in a model of liver hepatectomy in TGF-beta-overexpressing transgenic mice, in an acute model of liver disease and in a chronic model of dimethylnitrosamine (DMN)-induced liver fibrosis. 15723089 2005