Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 GeneticVariation disease BEFREE Thus, understanding the molecular mechanisms that contribute to CNV as a consequence of TIMP-3 mutations will provide insight into the pathophysiology in SFD and likely the neovascular component of the more commonly seen AMD. 31757977 2019
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 Biomarker disease BEFREE TIMP-3 suppression induces choroidal neovascularization by moderating the polarization of macrophages in age-related macular degeneration. 30594674 2019
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 GeneticVariation disease BEFREE These results provide new insights into the pathogenesis of SFD and other retinopathies linked to mutations in TIMP3, such as age-related macular degeneration. 30668888 2019
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 GeneticVariation disease BEFREE Understanding the molecular functions of wild-type and mutant TIMP3 will provide significant insights into the patho-physiology of SFD and perhaps AMD. 30129971 2019
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 Biomarker disease BEFREE We found that patients with neovascular AMD had lower plasma concentration of TIMP-3 (p = 0.028) than healthy controls. 30288950 2019
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 Biomarker disease BEFREE Interestingly, we observed increased expression of tissue inhibitor of metalloproteinase 3 (Timp3) during the aging process, a gene associated with AMD and Bruch's membrane integrity. 29514656 2018
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 Biomarker disease BEFREE We found that the expression level of LIPC, SLC16A8, and TIMP-3 was significantly associated with AMD pathology in both groups (LIPC: P = 0.008, SLC16A8: P < 0.001, TIMP-3: P < 0.001, respectively). 27966779 2017
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 Biomarker disease CTD_human A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. 26691988 2016
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 GeneticVariation disease BEFREE A rare penetrant TIMP3 mutation confers relatively late onset choroidal neovascularisation which can mimic age-related macular degeneration. 26493035 2016
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 GeneticVariation disease BEFREE A recent genome-wide association studies (GWAS) reported that rs9621532 near the tissue inhibitor of metalloproteinase 3 (TIMP3)/synapsin III (SYN3) region of 22q12.3 is associated with AMD. 23422939 2013
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 GeneticVariation disease BEFREE Recently, two genome-wide association studies with large cohorts both identified rs9621532, a new single nucleotide polymorphism (SNP) that is associated with advanced age-related macular degeneration (AMD) and located near the TIMP3 gene. 22171703 2012
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 Biomarker disease BEFREE With the sample size of our study, no relationship was found for AMD and the SNPs tested in complement 3 (C3); serpin peptidase inhibitor, clade G, member 1 (SERPING1); vascular endothelial growth factor (VEGF); cholesterol ester transfer protein (CETP); lipoprotein lipase (LPL); hepatic lipase (LIPC); and metallopeptidase inhibitor 3 (TIMP3) genes. 22618592 2012
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 GeneticVariation disease BEFREE These results confirm associations of AMD with variants near the TIMP3 gene and at loci involved in HDL metabolism. 21613373 2011
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 GeneticVariation disease BEFREE Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 20385819 2010
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 Biomarker disease LHGDN We also discuss briefly how, despite the lack of inherited mutations in the structural gene, the TIMP3 protein might play a role in the onset and progression of AMD. 16259644 2005
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 Biomarker disease BEFREE We also discuss briefly how, despite the lack of inherited mutations in the structural gene, the TIMP3 protein might play a role in the onset and progression of AMD. 16259644 2005
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 AlteredExpression disease BEFREE Our results were supported by significant accumulation and expression overlap of both TIMP-3 and EFEMP1 between the retinal pigment epithelia and Bruch membrane in the eyes of ML and AMD patients. 15123717 2004
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 Biomarker disease BEFREE Increased expression of TIMP-3 mRNA does not cause accumulation of TIMP-3 in the Bruch membrane of Sorsby fundus dystrophy nor is it likely to cause age-related macular degeneration. 14597066 2003
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 Biomarker disease BEFREE The previously unreported finding of TIMP-3 induced apoptosis of RPE cells may account for some of the early features seen in SFD and ARMD. 11801512 2002
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 AlteredExpression disease BEFREE Increased expression of TIMP-3 is also observed in other degenerative retinal diseases, including the more severe forms of age-related macular degeneration, the most common cause of blindness in the elderly in developed countries. 10854443 2000
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 Biomarker disease BEFREE The purpose of this study was to determine whether TIMP3 is a major susceptibility gene for the AMD phenotype. 9152225 1997
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 Biomarker disease BEFREE The authors' results suggest that TIMP3 is not a major factor in the cause of AMD, AVMD, and CACD. 9152224 1997
Entrez Id: 7078
Gene Symbol: TIMP3
TIMP3
0.500 Biomarker disease HPO