Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.360 Biomarker disease BEFREE TLR4 inhibitor attenuates amyloid-β-induced angiogenic and inflammatory factors in ARPE-19 cells: Implications for age-related macular degeneration. 26936827 2016
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.360 GeneticVariation disease BEFREE Even with previously verified samples sets and adequate study powers, the results did not confirm the reported associations of TLR3 rs3775291 and TLR4 rs4986790 with AMD in the three independent samples, individually or combined. 19628747 2009
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.360 Biomarker disease BEFREE Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration. 18172114 2008
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.360 GeneticVariation disease BEFREE Although an intronic SNP in TLR4 was associated marginally with AMD (P = 0.03), it was not possible to replicate a previous association with the rare coding SNP D299G in this gene (P = 0.6). 18385087 2008
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.360 Biomarker disease LHGDN No evidence was found of an association between TLR4, CCR2, and CCL2 and AMD (age-related macular degeneration) 18172114 2008
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.360 GeneticVariation disease BEFREE Analysis of CFH, TLR4, and APOE polymorphism in India suggests the Tyr402His variant of CFH to be a global marker for age-related macular degeneration. 16936080 2006
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.360 Biomarker disease CTD_human Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. 15829498 2005
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.360 Biomarker disease CTD_human Multiple logistic regression demonstrated an increased risk of AMD in carriers of the G allele at TLR4 residue 299 (odds ratio=2.65, P=0.025), but lack of an independent effect by T399I variant. 15829498 2005
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.360 Biomarker disease CTD_human Interestingly, the effect of TLR4, APOE and ABCA1 variants on AMD susceptibility was opposite to that of association with atherosclerosis risk. 15829498 2005
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.360 Biomarker disease CTD_human We examined toll-like receptor 4 (TLR4) as a candidate gene for AMD susceptibility because: (i) the TLR4 gene is located on chromosome 9q32-33, a region exhibiting evidence of linkage to AMD in three independent reports; (ii) the TLR4-D299G variant is associated with reduced risk of atherosclerosis, a chronic inflammatory disease with subendothelial accumulation; (iii) the TLR4 is not only a key mediator of proinflammatory signaling pathways but also linked to regulation of cholesterol efflux and (iv) the TLR4 participates in phagocytosis of photoreceptor outer segments by the RPE. 15829498 2005
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.360 GeneticVariation disease BEFREE Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. 15829498 2005
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.360 Biomarker disease CTD_human TLR4-D299G showed an additive effect on AMD risk (odds ratio=4.13, P=0.002) with allelic variants of apolipoprotein E (APOE) and ATP-binding cassette transporter-1 (ABCA1), two genes involved in cholesterol efflux. 15829498 2005
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.360 Biomarker disease CTD_human We examined D299G and T399I variants of TLR4 in a sample of 667 unrelated AMD patients and 439 unrelated controls, all of Caucasian ancestry. 15829498 2005