Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group HPO
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 CausalMutation group CLINVAR
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group CTD_human This region contains a novel locus for autosomal recessive early-onset parkinsonism, PARK6. 11254447 2001
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group BEFREE Mutations associated with early-onset autosomal recessive parkinsonism have been identified in the Parkin gene, and recently a second gene, PARK6, involved in early-onset recessive parkinsonism was localized on chromosome 1p35-36. 11462174 2001
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group BEFREE Phenotypic characterisation of autosomal recessive PARK6-linked parkinsonism in three unrelated Italian families. 11748730 2001
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group BEFREE To date, no pathology or functional imaging studies are available on PARK6-linked parkinsonism. 12447943 2002
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group BEFREE Two new AREP loci (PARK6 and PARK7) have been recently mapped on chromosome 1p and confirmed in independent datasets, suggesting that both might be frequent. 12548343 2002
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group LHGDN Two new AREP loci (PARK6 and PARK7) have been recently mapped on chromosome 1p and confirmed in independent datasets, suggesting that both might be frequent. 12548343 2002
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group BEFREE PARK6 is a common cause of familial parkinsonism. 12548371 2002
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group LHGDN PARK6 is a common cause of familial parkinsonism. 12548371 2002
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group BEFREE Recessively inherited mutations in parkin, DJ-1, and PINK1 have recently been linked to familial forms of parkinsonism. 15294138 2004
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group BEFREE The gene responsible for PARK6 Parkinson's disease, PINK1, does not influence common forms of parkinsonism. 15349859 2004
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group BEFREE The identification of a higher number of patients (5%) than controls (1%) carrying a single heterozygous mutation, along with previous positron emission tomography studies demonstrating a preclinical nigrostriatal dysfunction in PARK6 carriers, supports the hypothesis that haploinsufficiency of PINK1, as well as of other EOP genes, may represent a susceptibility factor toward parkinsonism. 15349860 2004
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group LHGDN All sites of mutations were novel, suggesting that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. 15349870 2004
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group BEFREE All sites of mutations were novel, suggesting that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. 15349870 2004
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group CTD_human These findings confirm that recessive mutations in PINK1 cause early-onset parkinsonism and expand the associated clinical phenotype. 15349871 2004
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group BEFREE These findings confirm that recessive mutations in PINK1 cause early-onset parkinsonism and expand the associated clinical phenotype. 15349871 2004
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group BEFREE The results indicate worldwide distribution of PARK6-linked parkinsonism. 15505170 2004
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group BEFREE Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability. 15824318 2005
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group BEFREE Thus, early-onset PD with dementia may be considered PINK1-linked parkinsonism. 15955953 2005
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group BEFREE PINK1, Parkin, and DJ-1 mutations in Italian patients with early-onset parkinsonism. 15970950 2005
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group BEFREE Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes. 16009891 2005
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group LHGDN Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes. 16009891 2005
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group BEFREE Recent data has demonstrated that mutations in PINK1, encoding PTEN-induced kinase 1, are a cause of early onset recessive parkinsonism (PARK6 locus). 16046032 2006
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group BEFREE Recently, a putative mitochondrial kinase, PINK1, has been found mutated in an inherited form of parkinsonism. 16207731 2005