Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice. 31813996 2020
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Mutations in LRRK2 are currently recognized as the most common monogenetic cause of Parkinsonism. 31664682 2019
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Several kinases have been implicated in the pathogenesis of Parkinson's disease (PD), most notably leucine-rich repeat kinase 2 (LRRK2), as LRRK2 mutations are the most common genetic cause of a late-onset parkinsonism that is clinically indistinguishable from sporadic PD. 31129265 2019
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE We performed Sanger sequencing of all coding LRRK2 and SNCA exons in a sample of 91 patients with Parkinsonism. 29248340 2018
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE These results indicate that the hep pathway plays an important role in Lrrk2-linked Parkinsonism in flies. 29268033 2018
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies. 28336296 2017
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE We review the literature of genetic PD autopsies from cases with molecularly confirmed PD or parkinsonism and summarize main findings on SNCA (n = 25), Parkin (n = 20, 17 bi-allelic and 3 heterozygotes), PINK1 (n = 5, 1 bi-allelic and 4 heterozygotes), DJ-1 (n = 1), LRRK2 (n = 55), GBA (n = 10 Gaucher disease patients with parkinsonism), DNAJC13, GCH1, ATP13A2, PLA2G6 (n = 8 patients, 2 with PD), MPAN (n = 2), FBXO7, RAB39B, and ATXN2 (SCA2), as well as on 22q deletion syndrome (n = 3). 29124790 2017
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 AlteredExpression group BEFREE The present findings support the notion that reduced/suppressed LRRK2 expression might delay or prevent motor symptoms and/or frank Parkinsonism in individuals at risk to suffer autosomal dominant Parkinsonism (AD-P) by blocking OS-induced neurodegenerative processes in the DAergic neurons. 28041945 2017
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of genetic Parkinsonism. 26536050 2016
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Genetic variability in DNM3 modifies age of onset for LRRK2 Gly2019Ser parkinsonism and informs disease-relevant translational neuroscience. 27692902 2016
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Only PD and parkinsonism cases were tested for SNCA and LRRK2 mutations. 27613114 2016
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Our findings in a representative series of index cases from families with ADPD emphasize the important contribution of LRRK2 G2019S and GBA (L444P and N370S) mutations to parkinsonism in Brazilian families. 27777137 2016
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Here, we used a two-step approach to identify compounds from the FDA-approved licensed drug library that could suppress neurite degeneration in LRRK2-G2019S parkinsonism. 26931464 2016
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE The present study also establishes that G2019S mutation leads to a reduction in lysosomal pH and increased expression of the lysosomal ATPase ATP13A2, a gene linked to a parkinsonian syndrome (Kufor-Rakeb syndrome), in brain samples from mouse and human LRRK2 G2019S carriers. 26251043 2015
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE EDS and RBD were always reported to start after the onset of parkinsonism in LRRK2-PD. 26177462 2015
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE It is also clear that LRRK2 interacts, either physically or genetically, with several other important proteins implicated in PD, suggesting that LRRK2 may be a central player in the pathways that underlie parkinsonism. 26008812 2015
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group CTD_human Methylmercury can induce Parkinson's-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells. 26558463 2015
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE LRRK2 p.G2019S mutation is a useful aid to diagnosis and modifiers of disease in LRRK2 parkinsonism may aid in developing therapeutic targets. 24355527 2014
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 PosttranslationalModification group BEFREE The role of the LRRK2 gene in Parkinsonism. 25391693 2014
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE LRRK2 mutations were identified in 40 of 2523 PD patients (1.6%) and not in other primary parkinsonian syndromes. 24816003 2014
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group CTD_human G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy. 25017139 2014
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE Variants of the MAPT gene have been suggested to be associated with Parkinson's disease (PD) and to modify the risk for leucine-rich repeat kinase 2 (LRRK2) Parkinsonism. 24559644 2014
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE Prior studies causally linked mutations in SNCA, MAPT, and LRRK2 genes with familial Parkinsonism. 23507417 2013
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group CTD_human Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: implication in autosomal recessive juvenile parkinsonism. 23046578 2013
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Leucine-rich repeat kinase 2 (LRRK2) mutation is the most common cause of genetic-related parkinsonism and is usually associated with Lewy body pathology; however, tau, α-synuclein, and ubiquitin pathologies have also been reported. 23664753 2013