Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.700 Biomarker group BEFREE Computational Investigation of RNA A-Bulges Related to the Microtubule-Associated Protein Tau Causing Frontotemporal Dementia and Parkinsonism. 30517788 2019
Entrez Id: 7054
Gene Symbol: TH
TH
0.700 Biomarker group BEFREE To overcome this problem, we developed a non-invasive intranasal delivery system, chitosan coated niosomes with entrapped pentamidine (inPentasomes), in the attempt to provide a novel pharmacological approach to ameliorate parkinsonism induced by subchronic MPTP administration in C57BL-6 J mice. inPentasomes, prepared by evaporation method was administered daily by intranasal route in subchronic MPTP-intoxicated rodents and resulted in a dose-dependent manner (0.001-0.004 mg/kg) capable for a significant Tyrosine Hydroxylase (TH) positive neuronal density rescue in both striatum and substantia nigra of parkinsonian mice. 30529726 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.700 Biomarker group BEFREE The assembly of tau protein into abnormal filaments and brain cell degeneration are characteristic of a number of human neurodegenerative diseases, including Alzheimer's disease and frontotemporal dementia and parkinsonism linked to chromosome 17. 30905766 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group BEFREE Finally, psychological distress robustly induced anxiety and Parkinsonian symptoms in WT rats and accelerated certain symptoms of PD in PINK1-KO rats. 31836946 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.700 GeneticVariation group BEFREE Tau aggregation and seeding analyses of two novel MAPT variants found in patients with motor neuron disease and progressive parkinsonism. 31027853 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.700 Biomarker group BEFREE Tau protein is found to be aggregated and hyperphosphorylated (p-tau) in many neurologic disorders, including Parkinson disease (PD) and related parkinsonisms, Alzheimer disease, traumatic brain injury, and even in normal aging. 31085590 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.700 GeneticVariation group BEFREE [<sup>11</sup> C]PBB3-PET can capture four-repeat tau pathologies characteristic of N279K mutant frontotemporal dementia and parkinsonism linked to chromosome 17/MAPT. 30773680 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group BEFREE Genetic atypical Parkinson's disease (PD) describes monogenic forms of PD that resemble idiopathic PD but feature prominent atypical clinical signs and symptoms and can be sub-grouped into i) atypical monogenic forms caused by mutations in the ATP13A2, DNAJC6, FBXO7, SYNJ1, VPS13C, and DCTN genes; ii) monogenic PD more closely resembling idiopathic PD, but associated with atypical features in at least a subset of cases (SNCA-, LRRK2-, VPS35-, Parkin-, PINK1-, and DJ-1-linked PD; iii) carriers of mutations in genes that are usually associated with other movement disorders but may present with parkinsonism, such as dopa-responsive dystonia. 31779813 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.700 Biomarker group BEFREE Four of 22 cases with severe putaminal MAPT deposition were documented as having developed parkinsonism. 31206007 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.700 Biomarker group BEFREE NF-L and tau protein in CSF might be useful for mortality prognosis in patients with parkinsonian disorders and should be investigated in larger studies. 31070772 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.700 GeneticVariation group BEFREE Genetic variation at the microtubule-associated protein tau locus is associated with clinical parkinsonism. 31234228 2019
Entrez Id: 7054
Gene Symbol: TH
TH
0.700 Biomarker group BEFREE Here, we investigated sex differences in motor deficits and tyrosine hydroxylase (TH) immunoreactivity induced by a progressive model of parkinsonism. 30690108 2019
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group BEFREE Twenty-nine of 109 probands with autosomal-recessive inheritance of parkinsonism (26.6%) were found to carry mutations in Parkin, PINK1, GBA, or HTRA2. 30788857 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.700 GeneticVariation group BEFREE The identification of mutations in MAPT, the gene that encodes tau, causing dementia and parkinsonism established the notion that tau aggregation is responsible for the development of disease. 28789904 2018
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.700 GeneticVariation group BEFREE Carbazole and 2-arylquinoline binding was only observed in cases with Alzheimer's disease and one case with frontotemporal dementia and parkinsonism linked to chromosome 17 exhibiting a R406W MAPT mutation. 29716656 2018
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.700 Biomarker group BEFREE The aggregation of NFTs, the abnormal hyperphosphorylation of tau protein, and the interaction between tau and alpha-synuclein may all contribute to the cell death and poor axonal transport observed in PD and Parkinsonism. 30333786 2018
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group BEFREE Mutation of hop-1 and pink-1 attenuates vulnerability of neurotoxicity in C. elegans: the role of mitochondria-associated membrane proteins in Parkinsonism. 30076829 2018
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.700 GeneticVariation group BEFREE The first mutations associated with frontotemporal lobar degeneration (FTLD) were found in the microtubule-associated protein tau (MAPT) gene on chromosome 17 in families with frontotemporal degeneration and parkinsonism (FTDP-17). 29253099 2018
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group BEFREE Mutations of PTEN-induced putative kinase 1 (PINK1) and the E3 ubiquitin (Ub) ligase parkin can cause familial parkinsonism. 29991771 2018
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.700 GeneticVariation group BEFREE MAPT mutation associated with frontotemporal dementia and parkinsonism (FTDP-17). 27905268 2017
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 GeneticVariation group BEFREE Familial Parkinsonism is associated with loss-of-function mutations in PINK1 and Parkin. 27593930 2017
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group BEFREE HTRA2 and PINK1 loss of function causes parkinsonism in humans and animals. 29050400 2017
Entrez Id: 7054
Gene Symbol: TH
TH
0.700 AlteredExpression group BEFREE Since TH protein has been shown to be involved in the dopamine-producing pathway in previous studies, our results indicate the possibility that manganese-mediated reduction of TH expression and phosphorylation via decreased expression of c-RET protein in neural cells is involved in parkinsonism induced by manganese. 28730349 2017
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.700 Biomarker group BEFREE PINK1-type of early-onset parkinsonism can occur in very young patients, and phenotypic expression of PINK1 mutations may depend on age of onset and ethnicity. 28062148 2017
Entrez Id: 7054
Gene Symbol: TH
TH
0.700 Biomarker group BEFREE In an in vivo MPTP-induced animal model of Parkinson's disease, oral administration of compound 5b showed neuroprotection of nigrostriatal dopaminergic neurons as revealed by tyrosine hydroxylase staining and prevention of MPTP-induced parkinsonism as revealed by motor behavioral assay of vertical grid test. 28332824 2017