Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 17
Gene Symbol: AAVS1
AAVS1
0.010 GeneticVariation phenotype BEFREE The aim of present study was to characterize the site-specific profile and metabolic effects of Ex-4 levels expressed from salivary glands (SG) in vivo, following adeno-associated virus-mediated (AAV) gene therapy in two different animal models of obesity prone to impaired glucose tolerance and T2DM, specifically, Zucker fa/fa rats and high fed diet (HFD) mice. 22808093 2012
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.010 Biomarker phenotype BEFREE Furthermore, other than its established role in regulating insulin secretion by β-cells, evidence is provided that adipocyte-specific ABCA1 prevents fat storage and the development of impaired glucose tolerance. 24992457 2014
Entrez Id: 368
Gene Symbol: ABCC6
ABCC6
0.010 Biomarker phenotype BEFREE Our results show that ARA can prevent diet-induced obesity and glucose intolerance in C5BL/6 mice and suggests that the mechanism responsible is related to the promotion of energy metabolism in skeletal muscle and brown adipose tissues. 29342124 2018
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
0.080 GeneticVariation phenotype BEFREE In vivo rimonabant and ibipinabant caused glucose intolerance in CB1 but not SUR1-KO mice. 22167524 2012
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
0.080 GeneticVariation phenotype BEFREE We conclude that the gradual development of glucose intolerance in patients with the SUR1-E1506K mutation might, as in the mouse model, result from impaired insulin secretion due a failure of insulin content to increase with age. 23903354 2013
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
0.080 GeneticVariation phenotype BEFREE We conclude that the polymorphisms of the SUR1 gene predicted the conversion from impaired glucose tolerance to type 2 diabetes and that the effect of these polymorphisms on diabetes risk was additive with the E23K polymorphism of the Kir6.2 gene. 15579791 2004
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
0.080 GeneticVariation phenotype BEFREE Our data corroborate the hypothesis that the dominant E1506K ABCC8 mutation, responsible for CHI, predisposes to the development of glucose intolerance and diabetes later in life. 20042013 2010
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
0.080 GeneticVariation phenotype BEFREE ABCC8 mutation carriers exhibited glucose intolerance, frank diabetes, or insulin-requiring diabetes since diagnosis. 22210575 2012
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
0.080 GeneticVariation phenotype BEFREE Each of the ABCC8 gene mutation carrier family members were diagnosed with diabetes as follows: the grandfather with type 2 diabetes at 35 years of age, the aunt with slowly-progressive insulin-dependent diabetes at 18 years of age, the mother with ketosis-onset insulin-dependent diabetes at 14 years of age, the sister with impaired glucose tolerance at 9 years of age, and the proband with transient neonatal diabetes at birth. 30068891 2018
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
0.080 GeneticVariation phenotype BEFREE For the ABCC8 exon 18 and the KCNJ11 variant, associations were stronger for studies of clinical diabetes than newly detected glucose intolerance. 15842514 2005
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
0.080 Biomarker phenotype BEFREE We conclude that moderate-to-vigorous PA may modify the risk of developing T2D associated with genes regulating insulin secretion (SLC2A2, ABCC8) in persons with IGT. 17636114 2007
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.050 GeneticVariation phenotype BEFREE The frequent ACE insertion/deletion polymorphism (I/D) is, albeit inconsistently, associated with impaired glucose tolerance and insulin resistance. 28835639 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.050 GeneticVariation phenotype BEFREE In addition, ACE genotypes were not significant predictors of insulin resistance and glucose intolerance either among men or among women after adjustment for age, body mass index, and hypertension. 9321743 1997
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.050 GeneticVariation phenotype BEFREE Therefore, we studied the association of the ACE gene I/D polymorphism with glucose intolerance and insulin resistance, and the contribution of this locus to genetic susceptibility to hypertension in non-insulin-dependent diabetic mellitus (NIDDM). 9544854 1998
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.050 GeneticVariation phenotype LHGDN The association of ACE gene D/I polymorphism with cardiovascular risk factors in a population from Rio de Janeiro. 18622495 2008
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.050 GeneticVariation phenotype BEFREE The purpose of this study was to investigate the relationship between the ACE gene I/D polymorphism and both insulin sensitivity and glucose intolerance in a large cohort of healthy subjects. 18235053 2008
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.030 Biomarker phenotype BEFREE Loss of ACE2 resulted in decreased weight gain but increased glucose intolerance, epicardial adipose tissue (EAT) inflammation, and polarization of macrophages into a proinflammatory phenotype in response to HFD. 26224885 2016
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.030 Biomarker phenotype BEFREE HFD-induced insulin resistance and glucose intolerance were exacerbated in ACE2-knockout (ACE2KO) mice but were alleviated by exogenous A1-7 in C57BL/6J mice. 29225087 2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.030 Biomarker phenotype BEFREE In previous studies, we first demonstrated that ACE2 knockout (ACE2(-/)(y)) mice exhibit impaired glucose tolerance or diabetes. 24911884 2014
Entrez Id: 11332
Gene Symbol: ACOT7
ACOT7
0.010 Biomarker phenotype BEFREE While the loss of Acot7 did not result in metabolic complications following a normal chow diet, a high-fat diet induced greater body weight gain, adiposity, and glucose intolerance in Acot7 KO mice. 31039008 2019
Entrez Id: 93
Gene Symbol: ACVR2B
ACVR2B
0.010 Biomarker phenotype BEFREE Transgenic and knock-out mice for the ACVR2B gene display various endocrine pancreas-related abnormalities, including islet hypoplasia and glucose intolerance, demonstrating the crucial role of ACVR2B in the regulation of pancreas development. 11334431 2001
Entrez Id: 100
Gene Symbol: ADA
ADA
0.020 GeneticVariation phenotype BEFREE To assess, by a house to house study, the prevalence of diabetes, impaired glucose tolerance (IGT) and their associated risk factors in Benghazi, Libya using 75 gram oral glucose tolerance test (OGTT) and ADA 1997 and WHO 1998 diagnostic criteria. 11852372 2001
Entrez Id: 100
Gene Symbol: ADA
ADA
0.020 Biomarker phenotype BEFREE According to ADA criteria, 588 (74.6%) women were normal, 46 (5.8%) had impaired fasting glucose, 82 (10.4%) had impaired glucose tolerance, 29 (3.7%) had both impaired fasting glucose and impaired glucose tolerance, and 43 (5.4%) had diabetes. 10388966 1999
Entrez Id: 9289
Gene Symbol: ADGRG1
ADGRG1
0.010 AlteredExpression phenotype BEFREE Adipose Tissue in Persons With HIV Is Enriched for CD4<sup>+</sup> T Effector Memory and T Effector Memory RA<sup>+</sup> Cells, Which Show Higher CD69 Expression and CD57, CX3CR1, GPR56 Co-expression With Increasing Glucose Intolerance. 30941121 2019
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.010 GeneticVariation phenotype BEFREE Significant interactions were observed between alcohol and ADH1b (rs1229984) with respect to LDL and between alcohol and ALDH2 (rs886205) with respect to IGT/diabetes. 20700531 2010