Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.550 Biomarker phenotype RGD Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats. 27465994 2017
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.550 Biomarker phenotype CTD_human Selective Tissue Distribution Mediates Tissue-Dependent PPARγ Activation and Insulin Sensitization by INT131, a Selective PPARγ Modulator. 28611668 2017
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.550 Biomarker phenotype CTD_human Arsenic induces diabetic effects through beta-cell dysfunction and increased gluconeogenesis in mice. 25367288 2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.550 AlteredExpression phenotype BEFREE Compared with WT littermates, adult Kiss1r KO females displayed dramatically higher BW, leptin levels, and adiposity, along with strikingly impaired glucose tolerance. 24937427 2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.550 Biomarker phenotype RGD Creation and preliminary characterization of a leptin knockout rat. 22948215 2012
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.550 GeneticVariation phenotype BEFREE We have shown that placental leptin gene DNA methylation levels were correlated with glucose levels (2-h post-OGTT) in women with IGT (fetal side: ρ=-0.44, P≤0.05; maternal side: ρ=0.53, P≤0.01) and with decreased leptin gene expression (n=48; ρ≥-0.30, P≤0.05) in the whole cohort. 20724651 2011
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.550 Biomarker phenotype CTD_human Anti-diabetic and anti-adipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone (KR-66344). 21315688 2011
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.550 Biomarker phenotype CTD_human INT131: a selective modulator of PPAR gamma. 19452630 2009
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.550 Biomarker phenotype BEFREE Single nucleotide polymorphisms (SNPs) in the ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL genes were associated with the conversion from impaired glucose tolerance (IGT) to type 2 diabetes mellitus (T2D) in the Finnish Diabetes Prevention Study (DPS). 18249219 2008
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.550 GeneticVariation phenotype BEFREE Two polymorphisms (Lys109Arg, Gln223Arg) in the extracellular domain of the leptin receptor predicted the conversion to type 2 diabetes in high-risk individuals with IGT. 15997246 2006
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.550 AlteredExpression phenotype BEFREE Other adipokines were examined, and both pioglitazone and metformin decreased plasma levels of resistin in IGT subjects, and pioglitazone (but not metformin) decreased plasma levels of leptin. 16118250 2006
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.550 GeneticVariation phenotype BEFREE Leptin receptor gene variation predicts weight change in subjects with impaired glucose tolerance. 15833934 2005
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.550 GeneticVariation phenotype BEFREE Leptin receptor gene polymorphisms are associated with insulin in obese women with impaired glucose tolerance. 11443193 2001
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.550 Biomarker phenotype BEFREE Abnormalities of sympathetic effects, including disturbances of leptin and beta3-adrenergic receptor signalling, are likely to cause obesity and impaired glucose tolerance in rodents and humans. 10855527 2000
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.550 GeneticVariation phenotype BEFREE To investigate the relationship between polymorphisms in the OB-R and OB genes and metabolic markers for obesity and glucose intolerance in a population of Nauruan men. 10490782 1999
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.550 GeneticVariation phenotype BEFREE Subjects with normoglycaemia (n = 117) and impaired glucose tolerance (n = 27, WHO criteria) were included in the analysis.Leptin values were higher in women. 9632122 1998
Entrez Id: 3630
Gene Symbol: INS
INS
0.400 Biomarker phenotype CTD_human Individuals with impaired glucose tolerance have increased proinsulin levels, despite normal glucose or C-peptide levels. 21779873 2012
Entrez Id: 3630
Gene Symbol: INS
INS
0.400 AlteredExpression phenotype BEFREE In animal models for type 2 diabetes the contents of preproinsulin mRNA are lowered, which might suggest that an impaired metabolism of preproinsulin mRNA contributes to the development of glucose intolerance and diabetes. 18621093 2009
Entrez Id: 3630
Gene Symbol: INS
INS
0.400 AlteredExpression phenotype LHGDN Mice expressing human INS transgenes in Ins1/Ins2 double knockout mice resulted in glucose intolerance likely due to impaired insulin secretion. 17127405 2007
Entrez Id: 3630
Gene Symbol: INS
INS
0.400 GeneticVariation phenotype BEFREE Defective proinsulin processing leads to glucose intolerance, but neither insulin resistance nor diabetes develop despite obesity. 16644867 2006
Entrez Id: 3630
Gene Symbol: INS
INS
0.400 Biomarker phenotype BEFREE In adults with impaired glucose tolerance (IGT) and obesity (OB), an elevated proinsulin (PI) is predictive of type 2 diabetes mellitus (DM) and precedes the diagnosis by 5-20 yr. 12364457 2002
Entrez Id: 3630
Gene Symbol: INS
INS
0.400 GeneticVariation phenotype BEFREE Oral glucose tolerance tests on subjects with the presenilin 2 Met239Val mutation unaffected by early onset familial Alzheimer's disease (mean age 35 years) and on their first-degree relatives without the mutation demonstrated no evidence of glucose intolerance or increased proinsulin secretion. 10362543 1999
Entrez Id: 3630
Gene Symbol: INS
INS
0.400 Biomarker phenotype BEFREE At 120' both insulin and proinsulin values increased from NGT to IGT, but with development of diabetes a reduction was seen in the responses. 9768375 1998
Entrez Id: 3630
Gene Symbol: INS
INS
0.400 Biomarker phenotype BEFREE We determined GAD and islet cell (ICA512) autoantibodies from 215 NIDDM individuals and from 14 individuals with impaired glucose tolerance (IGT) of 68 families, including 1 family with maturity-onset diabetes of the young (MODY) and 3 families ascertained specifically for a mixture of NIDDM and IDDM. 9250448 1997
Entrez Id: 3630
Gene Symbol: INS
INS
0.400 AlteredExpression phenotype BEFREE Both fasting and post-glucose levels of proinsulin were elevated in patients with diabetes, but not in the relatives with IGT or NGT. 7821172 1995