Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.580 GeneticVariation disease BEFREE Pediatric renal cell carcinoma (RCC) is a rare cancer that can be associated with inherited diseases including tuberous sclerosis complex (TSC) caused by germline mutations in TSC1 or TSC2. 27748010 2017
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.580 GeneticVariation disease BEFREE PBRM1 is a tumour suppressor gene and somatic mutations are found in 30-45% of sporadic clear cell (cc) RCC. 25911086 2016
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.580 Biomarker disease CTD_human Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. 22138691 2012
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.580 AlteredExpression disease BEFREE Von Hippel-Lindau (VHL) tumour suppressor gene inactivation is associated with clear cell renal cell carcinoma (CCRCC) development. 21547579 2011
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.580 GeneticVariation disease BEFREE The commonest histological type of renal cancer, clear cell renal cell carcinoma (cc RCC), is associated with genetic and epigenetic changes in the von Hippel-Lindau (VHL) tumour suppressor. 20964835 2011
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.580 GeneticVariation disease BEFREE To examine the significance of the methylation level of the p53 target and tumour suppressor genes apoptotic protease activating factor-1 (APAF-1) and death-associated protein kinase-1 (DAPK-1) in 80 microdissected tumour samples from transitional cell carcinoma (TCC) of the bladder and 80 tumour samples from clear-cell renal cell carcinoma (RCC) as well as from non-tumourous bladder and kidney tissue. 17133271 2007
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.580 Biomarker disease BEFREE Genetic changes of the E-cadherin and APC tumour suppressor genes in clear cell renal cell carcinoma. 15203750 2004
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.580 GeneticVariation disease BEFREE However, rare kindreds with familial CCRCC (FCRC) not linked to the VHL tumour suppressor gene have been described suggesting that further familial RCC susceptibility genes exist. 10807693 2000
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.580 GeneticVariation disease BEFREE Loss of heterozygosity (LOH) studies have suggested that somatic mutations of a tumour suppressor gene or genes on chromosome 3p are a critical event in the pathogenesis of non-familial renal cell carcinoma (RCC). 7881415 1995
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.580 GenomicAlterations disease CGI
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.580 CausalMutation disease CGI