Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 Biomarker phenotype BEFREE CDKN2A/p16 is found to be inactivated in a broad spectrum of solid tumors and in more than 80% of OSCC. 28939073 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 Biomarker phenotype BEFREE Our data support the feasibility of combining ChIP-seq and RNAi screens in solid tumors and highlight multiple p16(INK4a)/p19(ARF)-independent functions for Bmi1 in development and cancer. 23680149 2013
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 GeneticVariation phenotype BEFREE Several studies have described p16INK4A and prostaglandin E2 (PGE2) co-alterations in various solid tumors, including non-small cell lung cancer (NSCLC). 19212685 2009
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 PosttranslationalModification phenotype BEFREE Methylation of the p15INK4b promoter never seems to occur in solid tumors but is a major gene silencing mechanism in hematological malignancies. p14ARF and p16INK4a promoter methylation often occurs in solid tumors but also in leukemias and lymphomas. 15370242 2004
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 GeneticVariation phenotype BEFREE Role of p53 and p16 gene alterations in determining response to concurrent paclitaxel and radiation in solid tumor. 10210535 1999
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 Biomarker phenotype BEFREE Recent reports have supported cyclin-dependent kinase inhibitor 2 (CDKN2, also known as MTS1, INK4, p16) at 9p21 as a candidate tumor-suppressor gene in solid tumors. 9171998 1997
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 Biomarker phenotype BEFREE MTS1, a tumor suppressor gene located on chromosome 9p21, has been shown to be altered in a number of human tumor cell lines, primary solid tumors, and leukemias. 9402846 1997
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 Biomarker phenotype BEFREE The CDKN2 gene has been recently localized to a chromosomal region found to be deleted in leukemias and solid tumors. 8618438 1996
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 Biomarker phenotype BEFREE A feedback regulatory loop involving pRb, p16ink4a, and CDKs seems to regulate G1/S phases transition. p16ink4a and p15ink4b are deleted in high frequency in human cell lines and in some fresh solid tumors. 8724524 1996
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 GeneticVariation phenotype BEFREE Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene have been found at high frequency in cell lines derived from a variety of adult solid tumors. 7630190 1995
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 GeneticVariation phenotype BEFREE The p16 protein is a cyclin inhibitor encoded by a gene located in 9p21, which may have antioncogenic properties, and is inactivated by homozygous p16 gene deletion or, less often, point mutation in several types of solid tumors often associated to cytogenetic evidence of 9p21 deletion. 7833469 1995