Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | GeneticVariation | phenotype | BEFREE | The study did not meet its primary objective of demonstrating the anti-tumor activity of everolimus in PIK3CA amplification/mutation and/or PTEN loss patients with advanced solid tumors refractory to standard therapy. | 28330462 | 2017 | ||||
|
0.370 | Biomarker | phenotype | BEFREE | Although PTEN deficiency in solid tumors has been studied extensively, rare studies have investigated PTEN alteration in lymphoid malignancies. | 26655726 | 2015 | ||||
|
0.370 | Biomarker | phenotype | BEFREE | Moreover, AKT2 is also exclusively required for the maintenance and survival of other PTEN-deficient solid tumors, including breast cancer and glioblastoma. | 24838891 | 2014 | ||||
|
0.370 | Biomarker | phenotype | BEFREE | PTEN also modulates angiogenesis mediated by vascular endothelial growth factor (VEGF) via down-regulating PI3K/Akt pathway in many solid tumors. | 21360018 | 2012 | ||||
|
0.370 | GeneticVariation | phenotype | BEFREE | Although the tumor-suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is frequently mutated or deleted in a wide variety of solid tumors, some malignancies, including prostate cancer, exhibit undetectable PTEN protein without loss of PTEN gene. | 19787268 | 2009 | ||||
|
0.370 | GeneticVariation | phenotype | BEFREE | The PTEN (Phosphatase and Tensin homolog deleted on chromosome Ten) tumor suppressor gene is frequently mutated or deleted in a wide variety of solid tumors, and these cancers are generally more aggressive and difficult to treat than those possessing wild type PTEN. | 17300726 | 2007 | ||||
|
0.370 | Biomarker | phenotype | BEFREE | PTEN is an ubiquitously expressed tumor suppressor which plays a prominent role in the pathogenesis of many types of sporadic solid tumors, including breast cancer, as well as hematologic malignancies. | 17405772 | 2007 | ||||
|
0.370 | GenomicAlterations | phenotype | CGI |