Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.370 GeneticVariation phenotype BEFREE The study did not meet its primary objective of demonstrating the anti-tumor activity of everolimus in PIK3CA amplification/mutation and/or PTEN loss patients with advanced solid tumors refractory to standard therapy. 28330462 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.370 Biomarker phenotype BEFREE Although PTEN deficiency in solid tumors has been studied extensively, rare studies have investigated PTEN alteration in lymphoid malignancies. 26655726 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.370 Biomarker phenotype BEFREE Moreover, AKT2 is also exclusively required for the maintenance and survival of other PTEN-deficient solid tumors, including breast cancer and glioblastoma. 24838891 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.370 Biomarker phenotype BEFREE PTEN also modulates angiogenesis mediated by vascular endothelial growth factor (VEGF) via down-regulating PI3K/Akt pathway in many solid tumors. 21360018 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.370 GeneticVariation phenotype BEFREE Although the tumor-suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is frequently mutated or deleted in a wide variety of solid tumors, some malignancies, including prostate cancer, exhibit undetectable PTEN protein without loss of PTEN gene. 19787268 2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.370 GeneticVariation phenotype BEFREE The PTEN (Phosphatase and Tensin homolog deleted on chromosome Ten) tumor suppressor gene is frequently mutated or deleted in a wide variety of solid tumors, and these cancers are generally more aggressive and difficult to treat than those possessing wild type PTEN. 17300726 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.370 Biomarker phenotype BEFREE PTEN is an ubiquitously expressed tumor suppressor which plays a prominent role in the pathogenesis of many types of sporadic solid tumors, including breast cancer, as well as hematologic malignancies. 17405772 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.370 GenomicAlterations phenotype CGI