Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker phenotype BEFREE The activation of JAK2/STAT3 pathway has been reported to have critical roles in several solid tumors. 29545902 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker phenotype BEFREE Signal transducer and activator of transcription 3 (STAT3) plays a prominent role in the growth and invasion of several types of solid tumors. 30091994 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker phenotype BEFREE These findings increase our understanding of immune programming in lung tumorigenesis and provide a mechanistic basis for developing STAT3-based immunotherapy against this and other solid tumors.<i></i>. 28108629 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker phenotype BEFREE Cellular target for CpG-STAT3 inhibitors include non-malignant, tumor-associated myeloid cells, such as polymorphonuclear MDSCs, as well as cancer cells in acute myeloid leukemia, B cell lymphoma and in certain solid tumors. 28214929 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker phenotype BEFREE Constitutive activation of the signal transducer and activator of transcription 3 (STAT3) is associated with progression of pancreatic and other solid tumors. 27003603 2016
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker phenotype BEFREE STAT3 is a valuable biomarker for prognosis prediction and a promising therapeutic target in human solid tumors. 26959884 2016
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker phenotype BEFREE The aim of this study was to determine the maximum-tolerated dose (MTD), safety, pharmacokinetics, and pharmacodynamics of OPB-51602, an oral, direct signal transduction activator of transcription 3 (STAT3) inhibitor, in patients with refractory solid tumors. 25609248 2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker phenotype BEFREE Therefore, sugiol is the first compound regulating STAT3 activity via modulation of cancer metabolic pathway and we suggest the use of sugiol as an inhibitor of the STAT3 pathway for the treatment of human solid tumors with activated STAT3. 26212545 2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression phenotype BEFREE Abnormal activation of STAT3 and miR-21 plays a vital role in progression and invasion of solid tumors. 26690371 2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker phenotype BEFREE It has been shown that overexpression of signal transducer and activator of transcription 3 (Stat3) contribute to the progression and metastasis of various solid tumors and that silencing Stat3 inhibits tumor growth in several types of cancer. 24899100 2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression phenotype BEFREE Aberrant activation of the ubiquitous transcription factor STAT3 is a major driver of solid tumor progression and pathological angiogenesis. 24615012 2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker phenotype BEFREE The STAT3 decoy oligonucleotidewas found to be an effective antiangiogenic agent, which is likely to contribute to the overall antitumor effects of this agent in solid tumors.Taken together with the previously demonstrated antitumor activity of this agent, STAT3 decoy oligonucleotide represents a promising single agent approach to targeting both the tumor and vascular compartments in various malignancies. 24404126 2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression phenotype BEFREE In particular, members of the IL-6R family acting via the downstream STAT3 transcription factor play an important role in a number of solid tumors - including ovarian cancer - by altering the expression of target genes that impact on key phenotypes. 24388871 2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression phenotype BEFREE Numerous studies have demonstrated constitutive activation of STAT3 in a wide variety of human tumors, including hematological malignancies (leukemias, lymphomas, and multiple myeloma) as well as diverse solid tumors (such as head and neck, breast, lung, gastric, hepatocellular, colorectal and prostate cancers). 24388873 2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 PosttranslationalModification phenotype BEFREE STAT3 protein phosphorylation is a frequent event in various hematologic malignancies and solid tumors. 23872306 2013
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker phenotype BEFREE Signal transducer and activator of transcription 3 (Stat3) has been implicated in the development and progression of various solid tumors. 23382914 2013
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker phenotype BEFREE Previous work has instead suggested that STAT3 activation in solid tumors is more commonly induced by hyperactive growth factor receptors or autocrine cytokine signaling. 22319590 2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker phenotype BEFREE Hyperphosphorylation at the Y705 residue of signal transducer and activator of transcription 3 (STAT3) is implicated in tumorigenesis of leukemia and some solid tumors. 21840932 2011
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker phenotype BEFREE Because signal transducer and activator of transcription 3 (STAT3) is constitutively activated in most human solid tumors and is involved in the proliferation, angiogenesis, immune evasion, and antiapoptosis of cancer cells, researchers have focused on STAT3 as a target for cancer therapy. 19118003 2009