Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.200 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.200 AlteredExpression disease BEFREE SMAD4 gene inactivation is associated with poorer prognosis in patients with surgically resected adenocarcinoma of the pancreas. 19584151 2009
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.200 GeneticVariation disease BEFREE Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. 17349581 2007
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.200 AlteredExpression disease BEFREE This study examines SMAD4 expression in fine-needle aspiration cell blocks from patients with pancreatic adenocarcinoma, as well as a variety of human cancers, in order to assess its viability as a tumor marker. 17854080 2007
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.200 GeneticVariation disease BEFREE To assess whether alterations in the K-ras, p53, and DPC4 genes are present in pancreatitis, a potential precancerous condition that can progress to pancreatic adenocarcinoma. 17436386 2007
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.200 Biomarker disease BEFREE Genomic alterations influencing the expression and/or activity of tumor suppressors or oncogenes such as KRAS2, CDKN2A, TP53, and DPC4 have been directly implicated in the initiation and progression of human pancreatic adenocarcinoma. 15929091 2005
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.200 GeneticVariation disease BEFREE Cytogenetic, allelotype, and somatic cell hybrid studies in human pancreatic adenocarcinoma have suggested that chromosome 18 may carry tumor suppressor genes (TSGs), including SMAD4. 15084978 2004
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.200 AlteredExpression disease BEFREE The expression patterns of p16 and Smad4 were determined in a subset of PanINs by immunohistochemistry, and the pattern of labeling compared with that seen in PanINs associated with infiltrating adenocarcinoma of the pancreas as identified in prior studies, and to PanINs associated with pancreatic endocrine tumor. 14657708 2003
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.200 AlteredExpression disease BEFREE SEL1L expression in pancreatic adenocarcinoma parallels SMAD4 expression and delays tumor growth in vitro and in vivo. 14508516 2003
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.200 GeneticVariation disease BEFREE A nonsense mutation generating a C-terminal truncation of 38 amino acids in the Smad4 protein has been identified in a pancreatic adenocarcinoma (Hahn, S. A., Schutte, M., Hoque, A. T., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., and Kern, S. E. (1996) Science 271, 350-353), and here we investigate the functional consequences of this mutation. 11553622 2001
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.200 AlteredExpression disease BEFREE Patients undergoing Whipple resection for pancreatic adenocarcinoma survive longer if their cancers express SMAD4. 11751510 2001
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.200 AlteredExpression disease BEFREE To accomplish this, six established pancreatic cancer cell lines, twenty-six surgically resected tumor specimens of pancreatic adenocarcinoma and ten non-tumor pancreas tissues were analyzed for the mRNA expression of the three TGF-beta receptors (RI, RII, and RIII) and DPC4. 10769633 2000
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.200 Biomarker disease HPO