Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 GeneticVariation disease BEFREE DSRCT is associated with a recurrent t(11;22)(p13;q12) translocation, leading to the characteristic EWSR1-WT1 gene fusion. 28748349 2017
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 GeneticVariation disease BEFREE The presence of the EWS-WT1 gene fusion transcript (GFT) is characteristic of desmoplastic small round cell tumor (DSRCT), a rare and very aggressive disease for which the treatment has not yet been clearly standardized. 22162435 2012
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 Biomarker disease BEFREE A novel EWS-WT1 gene fusion product in desmoplastic small round cell tumor is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene. 16730884 2007
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 Biomarker disease BEFREE The current case emphasizes the utility of fluorescence in situ hybridization to demonstrate EWS-WT1 gene fusion in desmoplastic small round cell tumor with nonclassic morphologic and immunohistochemical features to avoid potential misdiagnosis. 17425400 2007
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 Biomarker disease BEFREE Other targets of the EWS-WT1 transcription factor other than PDGF-A may be directly responsible for the prominent tumor-associated desmoplasia seen in desmoplastic small round cell tumor. 15389255 2005
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 AlteredExpression disease BEFREE The dysregulated expression of EWS-WT1 targets contribute to the malignant phenotype of DSRCT and provide valuable insight regarding the molecular mechanisms underlying the development and progression of this distinct translocation associated tumor. 15826834 2005
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 Biomarker disease BEFREE Since this immunoprofile is characteristic of DSCT, molecular analysis was performed which revealed the presence of EWS-WT1 gene fusion characteristic of DSCT. 15166674 2004
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 Biomarker disease BEFREE To assess the expression and localisation of connective tissue growth factor (CCN2) in DSRCT because this protein is transcriptionally repressed by WT1 and is associated with the production of abundant extracellular matrix. 15047749 2004
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 Biomarker disease BEFREE A tetraspanin-family protein, T-cell acute lymphoblastic leukemia-associated antigen 1, is induced by the Ewing's sarcoma-Wilms' tumor 1 fusion protein of desmoplastic small round-cell tumor. 14633590 2003
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 Biomarker disease BEFREE Detection of the EWS-WT1 gene fusion is characteristic of desmoplastic small round cell tumor and has been used reliably in tumor diagnosis. 12640103 2003
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 GeneticVariation disease BEFREE Desmoplastic small round cell tumor is a rare, aggressive neoplasm that mainly affects young male patients and is characterized by a reciprocal translocation t(11;22)(p13;q12) associated with the EWS-WT1 gene fusion transcript. 12131150 2002
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 GeneticVariation disease BEFREE EWS-WT1 gene fusion characteristic of DSRCT with the t(11;22)(q13;q12) translocation was demonstrated in this tumor. 12296765 2002
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 GeneticVariation disease BEFREE A recently described member of this group is desmoplastic small round cell tumor (DSRCT), which is characterized by a recurrent t(11;22)(p13;q12) translocation that fuses the 5' exons of the EWS gene to the 3' exons of the WT1 gene. 11896622 2002
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 Biomarker disease BEFREE We studied the predictive value of immunohistochemistry with an antibody to the C-terminal region of the Wilms tumor (WT1) protein for differentiating DSRCT from EWS/PNET in 24 malignant small round cell tumors that had been previously diagnosed as DSRCT or EWS/PNET by standard methods. 10989634 2000
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 GeneticVariation disease BEFREE In addition, this patient demonstrates a rare variant of EWS-WT1 gene fusion not described in DSCT involving serosal surfaces. 10555010 1999
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 GeneticVariation disease BEFREE Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive malignancy characterized cytogenetically by a unique translocation of chromosomes 11 and 22 [t(11:22)(p13:ql2)], resulting in fusion of the EWS and WT1 genes. 10029456 1999
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 GeneticVariation disease BEFREE Desmoplastic small round-cell tumor of the paratesticular region: report of an adult case with demonstration of EWS and WT1 gene fusion using paraffin-embedded tissue. 10430278 1999
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 GeneticVariation disease BEFREE Novel breakpoints of the EWS gene and the WT1 gene in a desmoplastic small round cell tumor. 9797782 1998
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 GeneticVariation disease BEFREE Molecular variants of the EWS-WT1 gene fusion in desmoplastic small round cell tumor. 9646031 1998
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 Biomarker disease BEFREE Detection of the EWS/WT1 gene fusion by reverse transcriptase-polymerase chain reaction in the diagnosis of intra-abdominal desmoplastic small round cell tumor. 8604806 1996
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 Biomarker disease BEFREE A genomic DNA fragment containing the EWS-WT1 gene fusion has been isolated from a desmoplastic small round cell tumor, and the breakpoint has been characterized. 7862627 1995
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 Biomarker disease BEFREE EWS and WT-1 gene fusion in desmoplastic small round cell tumor of the abdomen. 8522311 1995
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 GeneticVariation disease BEFREE Desmoplastic small round cell tumor is a recently described entity associated with fusion of the EWS and WT1 genes and with expression of a chimeric transcript. 7495283 1995
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 Biomarker disease BEFREE Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor. 8187063 1994
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.600 FusionGene disease ORPHANET