Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE TP53 codon 72 polymorphism may predict early tumour progression in paediatric pilocytic astrocytoma. 27374106 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE TP53 mutations were present only in malignant gliomas, including three pGBMs and one case designated as PA with anaplastic features (with consultation opinion of pGBM). 24057326 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Our results indicate that PAs are senescent as evidenced by marked senescence-associated acidic β-galactosidase activity, low KI-67 index, and induction of p16(INK4a) but not p53 in the majority of 52 PA samples (46 of 52; 88.5%). 21610151 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease CTD_mouse Bioluminescent approaches for measuring tumor growth in a mouse model of neurofibromatosis. 20176786 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Our results showed that p53 alterations is an early event in astrocytic gliomagenesis, but is not significant in the evolution of pilocytic astrocytomas. 21133628 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Although in diffuse gliomas TP53 gene mutations or deletions occur with significant frequency, the role in pilocytic astrocytomas remains unclear. 16391789 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE We determined the frequency of aberrant CpG island methylation of several tumour-associated genes: MGMT, GSTP1, DAPK, p14ARF, THBS1, TIMP-3, p73, p16INK4A, RB1 and TP53 in 24 neurogenic tumours consisting of pilocytic astrocytomas (n=13) and medulloblastomas (n=11). 12684707 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE No SSCP alterations were observed in any of the p53 fragments amplified from WHO grade I pilocytic astrocytomas and WHO grade III anaplastic astrocytomas. 11724349 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Prior studies have shown that TP53 mutations may occur in up to 25% of PXAs, suggesting that PXA may have an etiology similar to diffuse astrocytoma rather than pilocytic astrocytoma. 11523567 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Significantly and in sharp contrast to diffuse astrocytomas, no pilocytic astrocytoma in our series stained for p53 protein. 11119125 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Our analysis of 20 pilocytic and two low-grade astrocytomas of childhood, based on a comprehensive denaturing gradient gel electrophoresis (DGGE) mutation detection assay of the entire coding region, including all splice site junctions of TP53, showed mutations considered as causative in 7 of the 20 (35%) pilocytic astrocytomas and in one of the two low-grade astrocytomas. 10416986 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE All primary tumors were histologically diagnosed as pilocytic astrocytoma (WHO grade I), except for one anaplastic pilocytic astrocytoma (WHO grade III) which developed in an NF1 patient and recurred as glioblastoma multiforme (WHO grade IV). p53 mutations were detected using an assay in yeast which tests the transcriptional activity of p53 proteins synthesized from tumor mRNA-derived p53-cDNA templates. 9626343 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE However, MIB-1 or p53 staining alone cannot differentiate pilocytic astrocytomas and astrocytomas from anaplastic astrocytomas and glioblastomas. 9839169 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE This is, to the authors' knowledge, the first report that shows a p53 mutation in pilocytic astrocytomas. 8666369 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE None of the fibrillary astrocytomas (grade II) or pilocytic astrocytomas (grade I) showed allelic imbalance at the p53 locus. 7494603 1995