Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE These findings indicate that BCA exerts its cytotoxic effects by promoting phosphorylation/ubiquitin-dependent degradation of β-catenin and may potentially serve as a chemopreventive agent for colonrectal and liver cancers. 31163223 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Tcf7l1 Acts as a Suppressor for the Self-Renewal of Liver Cancer Stem Cells and Is Regulated by IGF/MEK/ERK Signaling Independent of β-Catenin. 31322782 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Long non-coding RNA THOR promotes liver cancer stem cells expansion via β-catenin pathway. 30359743 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Anti-tumor effect of LATS2 on liver cancer death: Role of DRP1-mediated mitochondrial division and the Wnt/β-catenin pathway. 30981110 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE In conclusion, this study revealed that the reciprocal regulation between O-GlcNAcylation and β-catenin facilitated the proliferation of liver cancer. 30762425 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 AlteredExpression disease BEFREE Ribose-5-phosphate isomerase A overexpression promotes liver cancer development in transgenic zebrafish via activation of ERK and β-catenin pathways. 30418535 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Using data from The Cancer Genome Atlas, from the LIRI-JP (Liver Cancer - RIKEN, JP project), and from our transcriptomic, transfection and mouse transgenic experiments, we identify a GRN which functionally links LIN28B-dependent dedifferentiation with dysfunction of β-catenin (CTNNB1). 30953666 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 GeneticVariation disease BEFREE Mutations in <i>CTNNB1</i>, the gene encoding β-catenin, are common in colon and liver cancers, the most frequent mutation affecting Ser-45 in β-catenin. 31690625 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE β2 spectrin-mediated differentiation repressed the properties of liver cancer stem cells through β-catenin. 29555987 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Significantly, we also found that excessive β-catenin abrogated the effect of MEG3 in liver cancer. 29449541 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Mefloquine targets β-catenin pathway and thus can play a role in the treatment of liver cancer. 29578061 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Thyroid Hormone Receptor-β Agonist GC-1 Inhibits Met-β-Catenin-Driven Hepatocellular Cancer. 28807594 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Let7b modulates the Wnt/β-catenin pathway in liver cancer cells via downregulated Frizzled4. 28671046 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 GeneticVariation disease BEFREE The liver cancer-specific signature 16, associated with alcohol, displays a unique feature of transcription-coupled damage and is the main source of CTNNB1 mutations. 29101368 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Collectively, we conclude that suppression of both Sirt1 and Wnt/βCatenin might be effective in treating liver cancer. 28583374 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Knockout of ASIC1a by CRISPR/CAS9 inhibited liver cancer cell proliferation and tumorigenicity in vitro and in vivo through β-catenin degradation and LEF-TCF inactivation. 27462920 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Oncogenic dependency on β-catenin in liver cancer cell lines correlates with pathway activation. 29383099 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis. 28671671 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE Targeting β-catenin in hepatocellular cancers induced by coexpression of mutant β-catenin and K-Ras in mice. 27981621 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE We studied T-UCRs downstream of the Wnt/β-catenin pathway in liver cancer. 27618837 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 GeneticVariation disease BEFREE Antitumour activity of an inhibitor of miR-34a in liver cancer with β-catenin-mutations. 25792709 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 AlteredExpression disease BEFREE Hepatic cancer stem cell marker granulin-epithelin precursor and β-catenin expression associate with recurrence in hepatocellular carcinoma. 26942873 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 Biomarker disease BEFREE We aim to review the role of β-catenin pathway on hepatocarcinogenesis and liver cancer stem cell maintenance. 26811628 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 GeneticVariation disease BEFREE These results suggest that most colorectal and liver cancers with mutations in components of the β-catenin degradation complex do not strongly rely on extracellular Wnt ligand exposure to support optimal growth. 27851986 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.400 AlteredExpression disease BEFREE Furthermore, using TOPflash and reverse transcription‑quantitative polymerase chain reaction analysis, Wnt/β‑catenin signaling and the transcriptional regulation of Wnt/β‑catenin target genes including dickkopf Wnt signaling pathway inhibitor 1, axis inhibition protein 2 and cyclin D1 were observed to be markedly upregulated in liver cancer SP cells. 26956539 2016