Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.390 Biomarker disease BEFREE CCND1 silencing suppresses liver cancer stem cell differentiation through inhibiting autophagy. 31667787 2020
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.390 AlteredExpression disease BEFREE Treatment of the liver cancer stem cells with mefloquine markedly decreased the potential to undergo self-renewal at 10 μM concentration after 48 h. The results from western blot analysis showed significantly higher expression of cancer stem cell molecules β-catenin and cyclin D1 in LCSCs. 29578061 2018
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.390 Biomarker disease BEFREE Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-β/Smad-regulated liver cancer stem cell-like cells. 28415588 2017
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.390 Biomarker disease BEFREE Overall, Scrib inhibits liver cancer cell proliferation by suppressing the expression of three oncogenes, Yap1, c-Myc and cyclin D1, thereby functioning as a tumor suppressor in liver cancer. 28460446 2017
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.390 AlteredExpression disease BEFREE Furthermore, using TOPflash and reverse transcription‑quantitative polymerase chain reaction analysis, Wnt/β‑catenin signaling and the transcriptional regulation of Wnt/β‑catenin target genes including dickkopf Wnt signaling pathway inhibitor 1, axis inhibition protein 2 and cyclin D1 were observed to be markedly upregulated in liver cancer SP cells. 26956539 2016
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.390 Biomarker disease CTD_human Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. 27064257 2016
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.390 Biomarker disease BEFREE The results of this study suggest that NLK is aberrantly regulated in HCC, which might contribute to the mitogenic potential of tumor cells during the initiation and progression of hepatocellular carcinoma; this process appears to involve the induction of CDK2 and cyclin D1 and might provide a novel target for therapeutic intervention in patients with liver cancer. 20512928 2010
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.390 Biomarker disease BEFREE We coexpressed CCND1 with c-Met in mice and found CCND1 to cooperate with c-Met to promote liver cancer formation. 19118010 2009
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.390 Biomarker disease BEFREE Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation. 17546056 2007
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.390 GeneticVariation disease BEFREE The CCND1-ORAOV1-FGF19-FGF4-FGF3-TMEM16A-FADD-PPFIA1-CTTN (EMS1) locus at human chromosome 11q13.3 is amplified in head and neck tumors, esophageal cancer, Kaposi's sarcoma, bladder tumors, breast cancer, and liver cancer. 15942670 2005