TGF-β1 pathway affects the protein expression of many signaling pathways, markers of liver cancer stem cells, cytokeratins, and TERT in liver cancer HepG2 cells.
In this study, we developed a retroviral vector containing herpes simplex virus type-1-thymidine kinase (HSV1‑TK) and a short hairpin RNA for the human telomerase reverse transcriptase (hTERT) gene and investigated the antitumor effects in an in vitro and in vivo mouse model of liver cancer, monitored by PET image.
Real-time quantification of human telomerase reverse transcriptase mRNA in liver tissues from patients with hepatocellular cancer and chronic viral hepatitis.