| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.550 | Biomarker | disease | BEFREE | Generation of liver-specific TGF-α and c-Myc-overexpressing fibroblasts for future creation of a liver cancer porcine model. | 24806597 | 2014 | ||||
|
0.550 | Biomarker | disease | BEFREE | Here, we applied functional genomics approach to study step-by-step development of hepatocellular carcinoma (HCC) in the c-Myc/Tgfα transgenic mouse model of aggressive human liver cancer. | 21771728 | 2011 | ||||
|
0.550 | Biomarker | disease | BEFREE | Thus, TGF-beta signaling inactivation appears to cooperate with TGF-alpha in vivo to promote the formation of liver cancer that recapitulates molecular features of human HCC. | 20020490 | 2010 | ||||
|
0.550 | GeneticVariation | disease | BEFREE | Here, we analyzed in preneoplastic and neoplastic livers from Fisher 344 and Brown Norway rats, possessing different genetic predisposition to HCC, in transforming growth factor-alpha (TGF-alpha) and c-Myc-TGF-alpha transgenic mice, characterized by different susceptibility to HCC, and in human HCC: (i) iNOS function and interactions with nuclear factor-kB (NF-kB) and Ha-RAS/extracellular signal-regulated kinase (ERK) during hepatocarcinogenesis; (ii) influence of genetic predisposition to liver cancer on these pathways and role of these cascades in determining a susceptible or resistant phenotype and (iii) iNOS prognostic value in human HCC. | 18579559 | 2008 | ||||
|
0.550 | AlteredExpression | disease | BEFREE | One candidate is the hepatocyte mitogen transforming growth factor alpha (TGF-alpha); in HBV-infected patients with liver cancer, TGF-alpha and HBsAg accumulate in the same hepatocytes. | 9270035 | 1997 | ||||
|
0.550 | Biomarker | disease | RGD | Hepatocellular neoplasms induced by low-number pancreatic islet transplants in streptozotocin diabetic rats. | 9060843 | 1997 | ||||
|
0.550 | Biomarker | disease | CTD_human | Transgenic mouse models in carcinogenesis: interaction of c-myc with transforming growth factor alpha and hepatocyte growth factor in hepatocarcinogenesis. | 8807143 | 1996 |