Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 GeneticVariation disease BEFREE This multicentre, phase 1/2, open-label study enrolled adult patients with unresectable iCCA with FGFR2 fusion, who progressed, were intolerant or not eligible to first-line chemotherapy (NCT01752920). 30420614 2019
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 GeneticVariation disease BEFREE We demonstrate that the irreversible FGFR inhibitor TAS-120 provides clinical benefit in patients with resistance to BGJ398 or Debio 1347 and overcomes several FGFR2 mutations in ICC models.<i>This article is highlighted in the In This Issue feature, p. 983</i>. 31109923 2019
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 Biomarker disease BEFREE Conclusion: Our data provide a proof of principle that upfront treatment with the BGJ398 + ganetespib combo improves therapeutic targeting of FGFR2 fusions in an experimental setting, which may be relevant to precision medicine approaches to FF-driven ICC. 30067876 2019
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 Biomarker disease BEFREE Genomic studies have shown that FGFR2 aberrations are implicated in approximately 15% of intrahepatic cholangiocarcinomas, which make FGFR2 aberrations (Achilles heel) as potential novel targets in the management of cholangiocarcinoma. 31255945 2019
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 Biomarker disease BEFREE Using break-apart probes and by determining the ratios of FGFR2/chromosome enumeration probe (CEP) 10 double-color probes, we evaluated 122 ICCs for the presence of FGFR2 translocations and amplifications, respectively, by fluorescence in situ hybridization. 29514108 2018
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 Biomarker disease BEFREE Fibroblast growth factor receptor 2 (FGFR2) was demonstrated to correlate to the progression and prognosis of intrahepatic cholangiocarcinoma (ICC) by numerous evidences. 30160357 2018
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 Biomarker disease BEFREE Fibroblast growth factor receptor 2 ( FGFR2) fusions/translocations are present in 13% to 17% of intrahepatic cholangiocarcinomas. 29182496 2018
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 Biomarker disease BEFREE Thus, polyclonal secondary <i>FGFR2</i> mutations represent an important clinical resistance mechanism that may guide the development of future therapeutic strategies.<b>Significance:</b> We report the first genetic mechanisms of clinical acquired resistance to FGFR inhibition in patients with FGFR2 fusion-positive ICC. 28034880 2017
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 GeneticVariation disease BEFREE Analyses of genetic alterations have identified those that might be targeted therapeutically, such as fusions in the FGFR2 gene and mutations in genes encoding isocitrate dehydrogenases (in approximately 60% of iCCAs) or amplifications at 11q13 and 6p21 (in approximately 15% of HCCs). 28043904 2017
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 GeneticVariation disease BEFREE Specificities are observed for some alterations and anatomical subtypes: frequent fibroblast growth factor receptor 2 (FGFR2) and isocitrate dehydrogenase 1/2 (IDH1/2) alterations are specific to intrahepatic cholangiocarcinomas (ICCs), whereas frequent ERBB2 oncogene alterations are specific to extrahepatic cholangiocarcinomas (ECCs) and gallbladder carcinomas (GBCs). 28628842 2017
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 Biomarker disease BEFREE In 18 evaluable patients with FGFR genetic alterations, 3 confirmed partial responses (two intrahepatic cholangiocarcinomas (iCCA) with FGFR2 fusions and one urothelial cancer with FGFR2 and FGF19 amplification) and two durable stable disease at ⩾16 weeks with tumour reduction (FGFR2 fusion-positive iCCA and adrenocortical carcinoma with FGFR1 amplification) were observed. 28972963 2017
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 AlteredExpression disease BEFREE Recent genomic analysis of cholangiocarcinoma has revealed the presence of fibroblast growth factor receptor 2 (FGFR2) fusion proteins in up to 13% of intrahepatic cholangiocarcinoma (iCCA). 27216979 2016
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 GeneticVariation disease BEFREE Genetic analyses revealed that KRAS mutation was significantly more frequent in type 1 ICC, whereas IDH mutation and FGFR2 translocation were restricted to type 2 ICC. 27259014 2016
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 GeneticVariation disease BEFREE Screening of a cohort of 107 iCCA patients reveals that FGFR2 fusions represent the most recurrent targetable alteration (45%, 17/107), while they are rarely present in other primary liver tumours (0/100 of hepatocellular carcinoma (HCC); 1/21 of mixed iCCA-HCC). 25608663 2015
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 Biomarker disease CTD_human Genomic spectra of biliary tract cancer. 26258846 2015
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 Biomarker disease BEFREE Fibroblast growth factor receptor 2 translocations in intrahepatic cholangiocarcinoma. 24837095 2014
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 GeneticVariation disease BEFREE Four (14%) of the ICC cases featured novel gene fusions involving the tyrosine kinases FGFR2 and NTRK1 (FGFR2-KIAA1598, FGFR2-BICC1, FGFR2-TACC3, and RABGAP1L-NTRK1). 24563076 2014
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.400 GeneticVariation disease BEFREE FGFR2 fusions and ERRFI mutations may represent novel targets in sporadic intrahepatic cholangiocarcinoma and trials should be characterized in larger cohorts of patients with these aberrations. 24550739 2014