Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.070 GeneticVariation disease BEFREE Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74. 23354978 2013
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.070 AlteredExpression disease BEFREE Promoter methylation status and expression of estrogen receptor alpha in familial breast cancer patients. 21922275 2012
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.070 Biomarker disease BEFREE Features of hereditary breast cancer include an early age-of-onset and over-representation of the 'triple-negative' phenotype (negative for estrogen-receptor, progesterone-receptor and HER2). 19298662 2009
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.070 Biomarker disease BEFREE The identification of the second human estrogen receptor, ERbeta, raised a question of its role in hereditary breast cancer. 18405391 2008
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.070 GeneticVariation disease BEFREE Our results indicate for the first time the importance of inherited variants in the estrogen receptor coactivator genes PPARGC1A and PPARGC1B for familial breast cancer susceptibility. 16704985 2006
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.070 Biomarker disease BEFREE For example, if tamoxifen reduces the risk of breast carcinoma via its antiestrogenic effects, it is possible that this effect will be diminished in the largely estrogen receptor negative BRCA1-related hereditary breast carcinoma. 9241077 1997
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.070 GeneticVariation disease BEFREE The correlation reported previously, as well as our current findings, suggest that further investigations are warranted to understand the possible linkage of the ER gene locus to hereditary breast cancer. 7861463 1995