Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.070 | GeneticVariation | disease | BEFREE | Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74. | 23354978 | 2013 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Promoter methylation status and expression of estrogen receptor alpha in familial breast cancer patients. | 21922275 | 2012 | ||||
|
0.070 | Biomarker | disease | BEFREE | Features of hereditary breast cancer include an early age-of-onset and over-representation of the 'triple-negative' phenotype (negative for estrogen-receptor, progesterone-receptor and HER2). | 19298662 | 2009 | ||||
|
0.070 | Biomarker | disease | BEFREE | The identification of the second human estrogen receptor, ERbeta, raised a question of its role in hereditary breast cancer. | 18405391 | 2008 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Our results indicate for the first time the importance of inherited variants in the estrogen receptor coactivator genes PPARGC1A and PPARGC1B for familial breast cancer susceptibility. | 16704985 | 2006 | ||||
|
0.070 | Biomarker | disease | BEFREE | For example, if tamoxifen reduces the risk of breast carcinoma via its antiestrogenic effects, it is possible that this effect will be diminished in the largely estrogen receptor negative BRCA1-related hereditary breast carcinoma. | 9241077 | 1997 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | The correlation reported previously, as well as our current findings, suggest that further investigations are warranted to understand the possible linkage of the ER gene locus to hereditary breast cancer. | 7861463 | 1995 |