Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE We analyzed 113 DNA repair genes selected from either an exome sequencing or a candidate gene approach in the GENESIS study, which includes familial BC cases with no BRCA1 or BRCA2 mutation and having a sister with BC (N = 1,207), and general population controls (N = 1,199). 30303537 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE <b>Expert opinion</b>: The transition to multi-gene panels in breast cancer patients has improved the likelihood of capturing a rare variant in a well-established gene associated with hereditary breast cancer (e.g.<i>BRCA1 and BRCA2, TP53</i>). 31469018 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE Majority of the BRCA1 and BRCA2 mutations are associated with the risk of sporadic and familial breast cancer. 30430339 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE We report a BRCA2 pathogenic variant in a Senegalese family with hereditary breast cancer. 31060517 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE Certain genetic predisposition factors, such as BRCA1 and BRCA2 mutations play a pivotal role in familial breast cancer development in both males and females. 31228304 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE Since the discovery of BRCA1 and BRCA2, multiple high- and moderate-penetrance genes have been reported as risk factors for hereditary breast cancer, ovarian cancer, or both; however, it is unclear whether these findings represent the complete genetic landscape of these cancers. 30128536 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 Biomarker disease BEFREE The risk attributed to some of these genes (e.g., CDKN2A and PALB2 for BC) was similar to that observed for BRCA2. 30733081 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 AlteredExpression disease BEFREE Here, we used expression data of 391 patients with familial breast cancer including 195 non-BRCA1/A2 and 196 BRCA1 and/or BRCA2 cases from four independent studies by means of meta-analysis to find differences in gene expression signature between these two types of familial breast cancer. 30125992 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 Biomarker disease BEFREE The inheritance of mutated suppressor genes, such as BRCA1 and BRCA2, is acknowledged as an etiological factor in hereditary breast carcinoma (HBC). 31518337 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE The most important cause of developing hereditary breast cancer is germline mutations occurring in breast cancer (BCs) susceptibility genes, for example, BRCA1, BRCA2, TP53, CHEK2, PTEN, ATM, and PPM1D. 30552672 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE BC patients from 54 BRCA1 and BRCA2-negative families with elevated BC risk and 120 matched controls were considered for germline DNA whole exome sequencing. 30947698 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE Analysis of the pathogenic variants of BRCA1 and BRCA2 using next-generation sequencing in women with familial breast cancer: a case-control study. 31331294 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE Mutational analysis of BRCA1 and BRCA2 genes in women with familial breast cancer from different regions of Colombia. 31341521 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE Hereditary breast cancer is predominantly associated with germline mutations in the BRCA1 or BRCA2 genes. 29086229 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE We found that 20 index patients (2.4%) in the FBC group carried a BRCA1 or BRCA2 LGR, and the frequencies of BRCA1 and BRCA2 LGRs were 1.6% and 0.8%, respectively. 29582426 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE We have screened over 6,000 early-onset and/or familial breast cancer (BC) cases collected by the ENIGMA consortium for sequence variants in the 5' noncoding regions of BC susceptibility genes BRCA1 and BRCA2, and identified 141 rare variants with global minor allele frequency < 0.01, 76 of which have not been reported previously. 30204945 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE Germline promoter hypermethylation in BRCA1 and BRCA2 genes is not present in hereditary breast cancer patients. 29404838 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE People carrying pathogenic variants of the BRCA1 and BRCA2 genes are often referred to as those having predisposition for 'hereditary breast cancer'. 28939999 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE To elucidate the molecular basis of breast cancer in the Tunisian population, we performed exome sequencing on six BRCA1/BRCA2 mutation-negative patients with familial breast cancer and identified a novel frameshift mutation in RCC1, encoding the Regulator of Chromosome Condensation 1. 29363114 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE Our goal was to investigate the impact on splicing of a set of reported variants of BRCA2 exons 17 and 18 to assess their role in hereditary breast cancer and to identify critical regulatory elements that may constitute hotspots for spliceogenic variants. 28339459 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE BRCA1 and BRCA2 gene mutations are the most common cause of hereditary breast cancer. 29310340 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE Mutations in two high susceptibility BRCA1 and BRCA2 genes explain 16-40% of familial BC, while other high, moderate and low susceptibility genes explain up to 20% more of BC families. 28202063 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 Biomarker disease BEFREE Prospective cohort study of 6036 BRCA1 and 3820 BRCA2 female carriers (5046 unaffected and 4810 with breast or ovarian cancer or both at baseline) recruited in 1997-2011 through the International BRCA1/2 Carrier Cohort Study, the Breast Cancer Family Registry and the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, with ascertainment through family clinics (94%) and population-based studies (6%). 28632866 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 GeneticVariation disease BEFREE This is the first study to report the screening of miR genes and of BRCA2 3'-UTR in a large series of familial breast cancer cases. 26785832 2016
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.400 Biomarker disease BEFREE Breast cancers arising in the setting of the hereditary breast cancer genes BRCA1 and BRCA2 are most commonly classified as basal-like breast cancer (BLBC) or luminal breast cancer, respectively. 27708239 2016