Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.080 GeneticVariation disease BEFREE Some heterozygous variants in BRIP1 could contribute to Hereditary Breast Cancer through a defective DNA repair. 30230034 2019
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.080 GeneticVariation disease BEFREE Along these lines, in melanoma we found several somatic mutations in FANCJ, some of which were previously identified in hereditary breast cancer and Fanconi anemia. 24351291 2014
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.080 GeneticVariation disease BEFREE After excluding BRCA1 and BRCA2 mutations, factors proposed to contribute to familial breast cancer include: chance clustering of apparently sporadic cases, shared lifestyle, monogenic inheritance, i.e., dominant gene mutations associated with a high risk (TP53, PTEN, STK11), dominant gene mutations associated with a relatively low risk (ATM, BRIP1, RLB2), recessive gene mutations associated with horizontal inheritance patterns (sister-sister), and polygenic inheritance where susceptibility to familial breast cancer is thought to be conferred by a large number of low risk alleles. 24306927 2014
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.080 Biomarker disease BEFREE This conclusion is further supported by the direct and functional interaction between FANCJ and the hereditary breast cancer-associated gene product BRCA1. 21345144 2011
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.080 GeneticVariation disease BEFREE Six previously described variants within BRIP1 and five within PALB2 were screened in 192 patients with early-onset or familial breast cancer. 19763819 2010
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.080 GeneticVariation disease BEFREE Our results showed that exonic deletions or amplifications affecting the BRIP1 and CHK1 genes seem not to contribute to hereditary breast cancer susceptibility in the Finnish population. 20567916 2010
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.080 Biomarker disease BEFREE FANCJ (also known as BRIP1 or BACH1) is a DNA helicase that was originally identified by its direct interaction with the hereditary breast cancer protein, BRCA1. 20658644 2010
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
0.080 GeneticVariation disease BEFREE BRIP1 (BACH1) variants and familial breast cancer risk: a case-control study. 17504528 2007