Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1
0.400 Biomarker disease BEFREE Our meta-analysis showed that mutations in CFTR modestly increase the risk of PC, whereas no association was found between SPINK1 and PC. 30134356 2018
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1
0.400 GeneticVariation disease BEFREE We describe a case of malignant pancreatic cancer diagnosed in a young patient with chronic pancreatitis who is a SPINK 1 heterozygote gene mutation carrier. 27358244 2017
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1
0.400 GeneticVariation disease BEFREE The SPINK1 mutation frequency was significantly decreased in patients with PC in comparison with patients with idiopathic pancreatitis but varied not significantly in comparison with healthy controls. 25003218 2014
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1
0.400 GeneticVariation disease BEFREE The combined frequency of 2.5% was significantly higher than that of healthy subjects (0.38%), suggesting that the SPINK 1 mutation is an important risk factor for the development of pancreatic cancer. 19896093 2009
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1
0.400 Biomarker disease CTD_human The combined frequency of 2.5% was significantly higher than that of healthy subjects (0.38%), suggesting that the SPINK 1 mutation is an important risk factor for the development of pancreatic cancer. 19896093 2009
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1
0.400 Biomarker disease BEFREE To further analyze the clinical importance of SPINK1 in the development of pancreatic cancer, we examined the expression of SPINK1 and EGFR in pancreatic tubular adenocarcinomas and pancreatic intraepithelial neoplasm. 19737965 2009
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1
0.400 GeneticVariation disease BEFREE Patients with the N34S mutation presented with earlier symptom onset and more dilatation of the main pancreatic duct, followed by more frequent surgical and/or endoscopic intervention and pancreatic cancer development than those without SPINK1 mutations. 17238043 2007
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1
0.400 GeneticVariation disease BEFREE The SPINK1 mutations N34S and P55S occurred in five PC patients with a prevalence (4.1%) not significantly different from that observed (2.0%) in HC. 17072959 2006
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1
0.400 GeneticVariation disease BEFREE Mutations N34S and P55S of the SPINK1 gene in patients with chronic pancreatitis or pancreatic cancer and in healthy subjects: a report from Finland. 15764155 2005
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1
0.400 GeneticVariation disease BEFREE The aim of this study was to determine if patients who carry polymorphisms in SPINK1 and CFTR are at increased risk of developing pancreatic cancer through the development of chronic pancreatitis. 14688470 2004
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1
0.400 GeneticVariation disease BEFREE We report a case of pancreatic cancer associated with chronic calcifying pancreatitis in a patient with a homozygous N34S mutation in the SPINK1 gene. 15084977 2004
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1
0.400 GeneticVariation disease BEFREE The N34S mutation of SPINK1 appears not to be a distinct genetic risk factor in patients with sporadic pancreatic cancer. 12649567 2003
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1
0.400 GeneticVariation disease BEFREE The frequencies of the promotor polymorphisms of IL10-627A, IL10-1117A, TNF-238A and TNF-308A in patients with alcoholic chronic pancreatitis, idiopathic pancreatitis, SPINK1-N34S-associated chronic pancreatitis and pancreatic cancer did not differ significantly from the control group. 14560157 2003