Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Mutant p53 Together with TGFβ Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer. 27637888 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer. 27721407 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Cooperation of Musashi-2, Numb, MDM2, and P53 in drug resistance and malignant biology of pancreatic cancer. 28223335 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer. 29017057 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer. 28121262 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Genetic alterations in K-ras and p53 are thought to be critical in pancreatic cancer development and progression. 28742845 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease CTD_mouse Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. 26390243 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 PosttranslationalModification disease BEFREE The genomic alterations that commonly occur in pancreatic cancer include activation of KRAS2 and inactivation of p53 and SMAD4 (refs 2-4). 27281208 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE In addition, the patient tissues identified that the miR-19a/b level in pancreatic cancer tissues was conversely correlated with TP53 and TP53INP1 expression. 26531836 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE We previously observed an association between TP53 haplotypes based on four polymorphisms (rs17878362, rs1042522, rs12947788, and rs17884306) and the risk of colorectal and pancreatic cancer. 26226484 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE The circadian clock gene Bmal1 acts as a potential anti-oncogene in pancreatic cancer by activating the p53 tumor suppressor pathway. 26683776 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Oral bacteria in pancreatic cancer: mutagenesis of the p53 tumour suppressor gene. 26617937 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Together, our data support the critical role of autophagy in pancreatic cancer and show that inhibition of autophagy may have clinical utility in the treatment of these cancers, independent of p53 status. 24875860 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 PosttranslationalModification disease BEFREE Enhanced phosphorylation of p53 by microRNA-26a leading to growth inhibition of pancreatic cancer. 26189069 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function. 26113084 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Taken together, our data indicate that PRIMA-1 induces apoptosis in p53 mutant pancreatic cancer cells by promoting the re-activation of p53 and inducing proapoptotic signaling pathways, providing in vitro evidence for a potential therapeutic approach in pancreatic cancer. 24838627 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE We investigated the prevalence of germline mutations in APC, ATM, BRCA1, BRCA2, CDKN2A, MLH1, MSH2, MSH6, PALB2, PMS2, PRSS1, STK11, and TP53 in patients with pancreatic cancer. 25479140 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Other genetic alterations, including telomere shortening and the inactivation of tumor suppressor genes such as CDKN2A, TP53, and SMAD4, which encode p16, p53, and SMAD4, respectively, also contribute to the progression of pancreatic cancer. 24445769 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Chromosomal rearrangements leading to gene disruption were prevalent, affecting genes known to be important in pancreatic cancer (TP53, SMAD4, CDKN2A, ARID1A and ROBO2) and new candidate drivers of pancreatic carcinogenesis (KDM6A and PREX2). 25719666 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Here we report a systematic definition of how pancreatic cancer cells harboring mutant p53 respond to this combination therapy, by combining mathematical models with large-scale quantitative biologic analyses of single cells and cell populations. 26141863 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE pERK, pAKT and p53 as tissue biomarkers in erlotinib-treated patients with advanced pancreatic cancer: a translational subgroup analysis from AIO-PK0104. 25164437 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE Studies of the molecular pathology of pancreatic cancer have revealed that activation of KRAS, overexpression of cyclooxygenase-2, inactivation of p16(INK4A) and loss of p53 activities occurred in pancreatic cancer. 25152585 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Our study first demonstrated that overexpression of CRT contributed to the development and progression of PC through MEK/ERK-signaling pathway but independent of p53. 24264800 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Moreover, we report a positive association between Gli1 and MDM2 in PC cells, but their relationship with p53 is dependent on wild-type or mutant p53 status. 24289472 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE To investigate whether simultaneous depletion of both p53 and TAp63 can recapitulate the effect of mutant p53 expression in vivo, we used a mouse model of pancreatic cancer in which the expression of mutant p53 resulted in the rapid appearance of primary tumours and metastases. 23873029 2014