Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 367
Gene Symbol: AR
AR
1.000 AlteredExpression disease BEFREE βKlotho inhibits androgen/androgen receptor‑associated epithelial‑mesenchymal transition in prostate cancer through inactivation of ERK1/2 signaling. 29749458 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 GeneticVariation disease BEFREE Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer. 20104229 2010
Entrez Id: 367
Gene Symbol: AR
AR
1.000 AlteredExpression disease BEFREE In sum, our findings reveal a novel AR-coactivator binding mechanism that may have clinical implications for AR activity in prostate cancer. 22102282 2012
Entrez Id: 367
Gene Symbol: AR
AR
1.000 Biomarker disease BEFREE Thus, inhibiting ETV1 or blocking its interaction with AR may represent novel strategies in prostate cancer therapy. 19789348 2009
Entrez Id: 367
Gene Symbol: AR
AR
1.000 AlteredExpression disease BEFREE Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity. 16384856 2006
Entrez Id: 367
Gene Symbol: AR
AR
1.000 Biomarker disease BEFREE PCA3, as a therapeutic target in PCa, might be used to potentiate AR antagonists. 28668854 2017
Entrez Id: 367
Gene Symbol: AR
AR
1.000 Biomarker disease BEFREE Therefore, this review aims to summarize the tumor microenvironment and its impact on androgen receptor signaling in prostate cancer. 30528321 2019
Entrez Id: 367
Gene Symbol: AR
AR
1.000 Biomarker disease BEFREE Furthermore, ADT combined with vaccination, specifically a DNA vaccine encoding the ligand-binding domain of the AR, led to improved antitumor responses as measured by tumor volumes and delays in the emergence of castrate-resistant prostate tumors in two murine prostate cancer models (Myc-CaP and prostate-specific PTEN-deficient mice). 29051161 2017
Entrez Id: 367
Gene Symbol: AR
AR
1.000 Biomarker disease BEFREE The major topic areas discussed at this year's meeting included (a) new insights into prostate cancer biology and treatment; (b) approaches for accelerating precision medicine for prostate cancer; (c) prostate-specific membrane antigen-targeted therapy and imaging for prostate cancer; (d) updates on Poly (ADP-ribose) polymerase (PARP)-inhibitor clinical trial results; (e) the biology and role of prostate cancer stem cells; (f) new approaches for targeting the androgen receptor and other steroid hormone receptor pathways; (g) racial disparities in prostate cancer treatment and outcomes; (h) the role of the nervous system in prostate cancer development and progression; (i) the role of the WNT signaling pathway in normal prostate and prostate cancer biology; (j) novel immunotherapy approaches; and (k) the ecology of prostate cancer. 31334865 2019
Entrez Id: 367
Gene Symbol: AR
AR
1.000 Biomarker disease BEFREE Activation of β-catenin signaling in androgen receptor-negative prostate cancer cells. 22298898 2012
Entrez Id: 367
Gene Symbol: AR
AR
1.000 AlteredExpression disease BEFREE ARD-69 is capable of reducing the AR protein level by >95% in these prostate cancer cell lines and effectively suppressing AR-regulated gene expression. 30629437 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 GeneticVariation disease BEFREE Data from our group and others have shown that the genomic deletion of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor suppressor gene and the disruption of the ETS gene family have a central role in prostate cancer and are likely to be associated with Gleason grade. 23018874 2013
Entrez Id: 367
Gene Symbol: AR
AR
1.000 GeneticVariation disease BEFREE Despite the AR being one of the most studied and attended targets in cancer, those gain-of-function mutations in the receptor remain a significant challenge for the development of PCa therapies. 31698174 2019
Entrez Id: 367
Gene Symbol: AR
AR
1.000 Biomarker disease BEFREE Here, we show that loss of the PTEN tumor suppressor gene is associated with hyperactivation of the AR in human PCa cell lines. 19074897 2008
Entrez Id: 367
Gene Symbol: AR
AR
1.000 Biomarker disease BEFREE These data show that TRPS1 protein expression is regulated by androgens via the AR in human prostate cancer xenografts. 15613454 2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 AlteredExpression disease BEFREE In this study, we reported that KDM5C was highly expressed in PCa and CRPC specimens, and the high expression promoted CRPC cell proliferation through repressing phosphatase and tensin homolog (PTEN) gene epigenetically. 30921702 2019
Entrez Id: 367
Gene Symbol: AR
AR
1.000 Biomarker disease BEFREE Together, these contrasting PTEN effects on AR activity in the same prostate cancer cell line with different passage numbers suggest that PTEN, via distinct mechanisms, differentially regulates AR in various stages of prostate cancers. 15205473 2004
Entrez Id: 367
Gene Symbol: AR
AR
1.000 GeneticVariation disease BEFREE To evaluate the hypothesis that amplification of the AR gene is a cause for the failure of androgen deprivation therapy in prostate cancer, we studied whether AR amplification leads to gene overexpression, whether the amplified AR gene is structurally intact, and whether tumors with AR amplification have distinct biological and clinical characteristics. 9000575 1997
Entrez Id: 367
Gene Symbol: AR
AR
1.000 Biomarker disease BEFREE To assess AR alteration as a mechanism of treatment resistance, a mouse model (h/mAR-TRAMP) was used in which the murine AR coding region is replaced by human sequence and prostate cancer initiated by a transgenic oncogene. 19010817 2008
Entrez Id: 367
Gene Symbol: AR
AR
1.000 Biomarker disease BEFREE Our objective was to generate a novel cell line model representing the endocrine treatment naive prostate cancer for testing treatments that target the androgen receptor (AR) and androgen metabolism. 20687225 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE In summary, the results of our study demonstrate that the deletion of 16q and PTEN cooperatively drives prostate cancer progression, and suggests that deletion analysis of 16q and PTEN could be of important clinical value particularly for preoperative risk assessment of the clinically most challenging group of low- and intermediated grade prostate cancers. 26009879 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE Knockdown of Phospholipase Cε (PLCε) Inhibits Cell Proliferation via Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN)/AKT Signaling Pathway in Human Prostate Cancer. 29330357 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE We previously demonstrated that MMAC1/PTEN has tumor suppressive properties in glioblastoma and prostate cancer. 11103942 2000
Entrez Id: 367
Gene Symbol: AR
AR
1.000 AlteredExpression disease BEFREE We have examined the inhibitory effect of rStd on androgen action in the human prostate cancer-derived PC-3 cells transfected with the rat androgen receptor (AR) expression plasmid and two androgen-responsive promoter reporter constructs (murine mammary tumor long-terminal repeat ligated to chloramphenicol acetyltransferase (CAT) gene and rat probasin androgen response element (ARE) ligated to firefly luciferase (LUC) gene). 9566751 1998
Entrez Id: 367
Gene Symbol: AR
AR
1.000 Biomarker disease BEFREE Taken together, these results suggest that AR-regulated WNT7B signaling is critical for the growth of CRPC and development of the osteoblastic bone response characteristic of advanced prostate cancer. 23386686 2013