Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE The data presented here suggest a therapeutic potential of targeting mutant p53 protein in advanced PCa setting, which has a clinical impact for aggressive PCa with transforming how such tumors are managed. 31471556 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE In this study, we found that hexokinase 2 (HK2), which has dual metabolic and apoptotic functions, is downstream of zinc and p53 in both prostate cancer patient tissue and prostate cancer cell lines. 30528266 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Overall, no association was observed between TP53 gene codon72 polymorphism and prostate cancer risk (Arg vs Pro: odds ratio [OR] = 1.12, 95% confidence interval [CI] = 0.98-1.30; ArgArg vs ProPro: OR = 1.26, 95% CI = 0.90-1.75; ProPro vs ArgArg+ ArgPro: OR = 1.17, 95% CI = 0.86-1.57; ArgPro+ ProPro vs ArgArg: OR = 1.21, 95% CI = 0.97-1.51). 31232967 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE High PF4V1 expression (normalized by TP53) was associated with poor disease-free survival (DFS) and good overall survival (OS) in PCa (<i>P</i><0.05). 30962718 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE The goal of this study was to evaluate the effects of 8-wk aerobic exercise training and administration of green tea extract on the level of nuclear factor kappa B (NF-kB), cyclooxygenase-2 (COX-2) and p53 tumor suppressor protein (p53) in prostate of rats which were stimulated by N-methyl-N-nitrosourea to induce the prostate cancer. 31626054 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE In prostate cancer (PCa), however, it has not been investigated whether and how p53 regulates EMT by circRNAs and miRNAs. 30531834 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE This updated analysis of a previously published study investigated the association between p53 aberrations, MR and PCSM in men with localised PC. 31409910 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Our present study provides compelling evidence that pharmacological activation of the p53 by blocking the MDM2-p53 interaction is a promising cancer therapeutic strategy and using RITA in combination with Cisplatin not only decrease the toxic effect of Cisplatin by decreasing its dose but also increasing the apoptotic effect, warrants clinical evaluation on both colon and prostate cancer. 31759358 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE We demonstrated that PEITC inhibits the growth of prostate cancer cells with different "hotspot" p53 mutations (structural and contact), however, preferentially towards structural mutants. 31307507 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Our results indicate that targeting ACO2 through zinc and p53 can change prostate cancer metabolism, and thus provides a potential new therapeutic strategy for prostate cancer. 30972978 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Further top five genes viz Rhoa, PI3KCA, CDC42, MAPK3, TP53 were used for Enrichment analysis which revealed their association with vital cellular and functional pathways in prostate cancer indicating their potential as candidate biomarkers in prostate cancer. 30937635 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE Our data, therefore, suggest that enzalutamide's high efficacy is at least partially independent of AR and p53 protein expression, which are frequently lost in advanced PC. 31297844 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Recent genome analysis of human prostate cancers demonstrated that both AR gene amplification and TP53 mutation are among the most frequently observed alterations in advanced prostate cancer. 31358900 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE At the same time, a series of transcription factors (relating to RELA, SOX10, TP53, and TWIST2, etc.) were obtained and may play a key regulatory role in prostate cancer PC-3 cell-related modules. 31539119 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Exosome-derived miR-27a produced by PSC-27 cells contributes to prostate cancer chemoresistance through p53. 31153637 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE Prostate cancer cell lines LNCaP and PC3 were treated with X-rays and AICAR then assessed for clonogenic survival, spheroid growth delay, cell cycle progression, and AMPK and p53 activity. 30774777 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE TP53 mutation is associated with higher tumor-infiltrating T-cell density, which may be relevant in future clinical trials of immunotherapy in prostate cancer. 30851334 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE ING5 inhibits cancer aggressiveness by inhibiting Akt and activating p53 in prostate cancer. 31475765 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE The aim of this study was to characterize TP53 mutations and treatment history in prostate cancer. 31822380 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE TP53, PTEN, and RB1 tumor suppressor genes (TSGs) are recurrently altered in treatment-resistant prostate cancer. 30553611 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE While PTEN inactivation leads to PC, it is not sufficient for metastasis, the loss of PTEN concurrently with the inactivation of both TP53 and RB1 empower lineage plasticity in PC cells, which substantially promotes PC metastasis and the conversion to PC adenocarcinoma to neuroendocrine PC (NEPC), demonstrating the essential function of TP53 and RB1 in the suppression of PCSCs. 30934773 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Prostate cancer is a common health problem among men worldwide and most of these prostate cancer cases are related to a dysfunctional mutant Tumor Protein p53 (TP53) gene. 31571107 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE The goal of this study was to evaluate the effects of eight-week aerobic exercise training and administration of green tea extract on the level of nuclear factor kappa B (NF-kB), cyclooxygenase-2 (COX-2) and p53 tumor suppressor protein (p53) in prostate of rats which were stimulated by N-Methyl-N-nitrosourea (NMU) to induce the prostate cancer. 31157709 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE In conclusion, Andro increases the sensitivity of PCa cells to TRAIL-induced apoptosis through the generation of ROS and up-regulation of p53 and then promotes PCa cell apoptosis associated with the activation of DR4. 28869219 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE By conducting transcriptome analysis, denaturing immunoprecipitations and immunopathology, we demonstrate that the TP53-MDM2-AR-AKT cross-talk is regulated by the deubiquitinating enzyme USP12 in prostate cancer. 29755129 2018