Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE Our results indicate that PCa family history may be positively associated with PCa in all ERG and PTEN subtypes, suggesting a role of genetic susceptibility in their development. 31318977 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE Multivariable Cox proportional hazard models were used to assess the association of <i>PTEN/ERG</i> status with lethal prostate cancer (defined as metastasis or prostate cancer specific death), adjusting for patient age, race, pathological grade and stage, and surgical margin status. 31502941 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE We used multivariable Cox regression to examine associations between statins and prostate cancer risk overall, by measures of clinically-significant disease, and by ERG and PTEN status. 31754047 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 AlteredExpression disease BEFREE In this study, we reported that KDM5C was highly expressed in PCa and CRPC specimens, and the high expression promoted CRPC cell proliferation through repressing phosphatase and tensin homolog (PTEN) gene epigenetically. 30921702 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE PTEN is a ubiquitous tumor suppressor that is often decreased in prostate cancer during tumor progression. 31213464 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 AlteredExpression disease BEFREE <b>Conclusions:</b> Our results reveal a previously unidentified cooperative role of RUNX2 overexpression and PTEN haploinsufficiency in prostate tumorigenesis, suggesting that the defined RUNX2-CXCR7-AKT axis can be a viable target for effective treatment of PCa. 31281490 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 AlteredExpression disease BEFREE While PTEN inactivation leads to PC, it is not sufficient for metastasis, the loss of PTEN concurrently with the inactivation of both TP53 and RB1 empower lineage plasticity in PC cells, which substantially promotes PC metastasis and the conversion to PC adenocarcinoma to neuroendocrine PC (NEPC), demonstrating the essential function of TP53 and RB1 in the suppression of PCSCs. 30934773 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE PTEN (Phosphatase and Tensin Homolog) mutant is the top common mutated genes in prostate cancer, which makes it a promising biomarker in future individualized treatment. 31791268 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE PTEN loss was rare among men with GS6 prostate cancer enrolled in AS at Johns Hopkins. 30279579 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE Metabolic reprogramming is one of the contributors to PTEN-loss driven prostate cancer. 30854061 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE PTEN loss was significantly (P < 0.05) associated with increasing GG, poorly formed glands (74% of total cases with loss vs 49% of intact), and three well-validated unfavorable pathological features: intraductal carcinoma of the prostate (IDC-P) (69% of total cases with loss vs 12% of intact), cribriform Gleason pattern 4 (38% of total cases with loss vs 10% of intact) and stromogenic PCa (23% of total cases with loss vs 6% of intact). 31111513 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 AlteredExpression disease BEFREE We surmise that the cumulative impact of factors such as the pre-treatment immune status, PTEN expression, DNA damage repair gene mutations, and the effects of conventionally used treatments on the anti-tumor immune response should be considered in immunotherapy trial design in PCa. 30984182 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE The aim of this study has been to analyze the immunohistochemical (IHC) expression of MSH2, MSH6, MLH1, PMS2, ERG, and PTEN and their potential association with the grade group (GG) grading system (WHO 2016) and PSA recurrence in a series of 200 PrCa (PSMAR-Biobank, Barcelona, Spain). 31209634 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 GeneticVariation disease BEFREE We have investigated ETV1, ETV4, and ETV5 overexpression, with or without PTEN loss, and their association with grade group (GG), pathological stage, focality, and PSA recurrence in PrCa. 31016435 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 AlteredExpression disease BEFREE We compared immunohistochemical expression for PTEN and ERG on prostate biopsy cores from patients with Grade Group (GG) 1 or GG2 prostate cancer who had undergone systematic biopsy with concurrent targeted biopsy. 31075299 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE We assessed the combined value of TFF3 and PTEN in two cohorts: one is managed surgically for localized PCa and the second is managed non-surgically by androgen deprivation therapy for advanced disease. 31129769 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE In PTEN-deficient prostate cancers, AKT signaling may be activated upon suppression of androgen receptor signaling. 30773595 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE FoxP3+ T regulatory cells (Tregs) were significantly increased in PTEN-deficient PCa in all three public domain cohorts. 30999388 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE In PTEN wild-type PCa, GRB10 overexpression promoted mediated PTEN interaction and degradation. 30379590 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE TP53, PTEN, and RB1 tumor suppressor genes (TSGs) are recurrently altered in treatment-resistant prostate cancer. 30553611 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer. 30496141 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE Moreover, the GAS5/miR-21/PDCD4/PTEN and GAS5/miR-1284/AKT signaling pathway was found to be closely related to the tumorigenesis of PC. 30317620 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE Loss of the tumor suppressor PTEN, a frequent event in prostate cancer, leads to PTK6 activation at the plasma membrane and its oncogenic signaling. 30926642 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE Here, we analyzed the immunohistochemical expression of CEBPA in a tissue microarray containing more than 17 000 prostate cancer specimens with annotated clinical and molecular data including for example TMPRSS2:ERG fusion and PTEN deletion status. 30430607 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
1.000 Biomarker disease BEFREE The results of our study suggest that combined PSP94/PTEN analysis can be potentially used in the clinical prognosis of prostate cancer. 31516752 2019