Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
0.380 Biomarker disease BEFREE And the inhibitor of SREBP1 and mTOR may help to prevent HCC in clinical NAFLD patients. 31409773 2019
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
0.380 AlteredExpression disease BEFREE The beneficial role of melatonin in dietary induced NAFLD/NASH in mice was related to reduced expression of microRNA-34a-5p and sterol regulatory element-binding protein (SREBP1) but only in the presence of full SIRT1 availability. 31500354 2019
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
0.380 Biomarker disease BEFREE Further upstream, EGFR inhibition suppressed AKT signaling, which is known to control these transcription factors, including PPARγ and SREBF1, in NAFLD models. 31063640 2019
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
0.380 Biomarker disease BEFREE RES prevented the development and progression of NAFLD and significantly improved insulin sensitivity through (1) inhibiting the proteolytic cleavage of SREBPs-1 and SREBPs-2 without affecting their precursor mRNA or protein levels, (2) inhibiting free fatty acid β-oxidation and generation of reactive oxygen species through significant inhibition of CPT-1 and UCP-2, and (3) decreasing activity of pancreatic lipase in vivo and in vitro. 28777914 2018
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
0.380 AlteredExpression disease BEFREE FRVE exhibited lipid-lowering effects by lowering sterol regulatory element-binding protein 1 and triglyceride levels, and promoting the activation of peroxisome proliferator-activated receptor and AMP-activated protein kinase in an in vitro model of non-alcoholic fatty liver. 30165848 2018
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
0.380 GeneticVariation disease BEFREE In conclusion, this study demonstrated a novel mechanism in which NAFLD associated with BPA exposure arose from alterations in the miR-192-SREBF1 axis. 28483554 2017
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
0.380 Biomarker disease BEFREE Sterol regulatory element-binding protein (SREBP) 1, the master regulator of lipogenesis, was shown to be associated with non-alcoholic fatty liver disease, which is attributed to its major isoform SREBP1c. 25634759 2015
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
0.380 Biomarker disease CTD_human Non-alcoholic fatty liver disease is associated with inhibited AMP-activated kinase (AMPK) and activation of sterol regulatory element binding protein 1 (SREBP-1). 24633463 2014
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
0.380 Biomarker disease CTD_human Amelioration by chicory seed extract of diabetes- and oleic acid-induced non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) via modulation of PPARα and SREBP-1. 23603006 2013
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
0.380 Biomarker disease BEFREE Amelioration by chicory seed extract of diabetes- and oleic acid-induced non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) via modulation of PPARα and SREBP-1. 23603006 2013