Using the fluorescence resonance energy transfer (FRET) technique, we provide direct evidence that D2R hyperactivity led to D2R-DISC1 complex formation, which altered pGSK3β signalling.
Furthermore, results demonstrated a differential behavioral effect between maternal deprivation and Disc1 deficiency, with maternal deprivation associated with a hyperactive phenotype and impaired prepulse inhibition, and Disc1 deficiency causing an impairment in fear conditioning.
These results suggest that cognitive impairments accompanied by perseverative/compulsive behaviors in Disc1<sup>Δ2-3/Δ2-3</sup> mice are associated with hyperactivity of the DMS.