Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.300 Therapeutic phenotype CTD_human Evidence for antagonistic activity of endothelin for clonidine induced hypotension and bradycardia. 1309933 1992
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.300 Therapeutic phenotype CTD_human ET-1 significantly (P < 0.0005) potentiated the hypertensive response of a low dose (50 micrograms/kg i.v.) of clonidine in cervical-sectioned rats.I.c.v. administration of clonidine (1, 2, 4 and 6 micrograms) produced a dose-dependent decrease in blood pressure and heart rate.ET-1 pretreatment (25 ng i.c.v.) transiently blocked the clonidine-induced decrease in blood pressure and heart rate for about 10 min but the hypotension and bradycardia was observed subsequently. 8440307 1993