Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 51155
Gene Symbol: JPT1
JPT1
0.010 Biomarker disease BEFREE We further identified that silencing of JPT1 abundance does not alter cellular response to metformin or basal cell proliferation, but that JPT1 abundance does decrease in response to metformin treatment in RL95-2 and ACI-181 EC cell lines. 31808620 2020
Entrez Id: 3965
Gene Symbol: LGALS9
LGALS9
0.010 AlteredExpression disease BEFREE The Significance of Galectin-1 and Galectin-9 Expression in Endometrial Carcinoma. 31487707 2020
Entrez Id: 10752
Gene Symbol: CHL1
CHL1
0.010 Biomarker disease BEFREE Knockdown of CHL1-AS1 or CHL1 inhibited cell proliferation and migration in EC. 31736153 2020
Entrez Id: 101927193
Gene Symbol: CHL1-AS1
CHL1-AS1
0.010 Biomarker disease BEFREE Knockdown of CHL1-AS1 or CHL1 inhibited cell proliferation and migration in EC. 31736153 2020
Entrez Id: 3956
Gene Symbol: LGALS1
LGALS1
0.010 AlteredExpression disease BEFREE The expression of Galectin-1 and -9 in the EC and AH was significantly higher than that in the NE (p< 0.05). 31487707 2020
Entrez Id: 8241
Gene Symbol: RBM10
RBM10
0.010 AlteredExpression disease BEFREE VEGFA alternative splicing in endometrial cancer was regulated by RBM10, the expression of which was controlled by histone acetylation and DNA methylation. 31587503 2020
Entrez Id: 55799
Gene Symbol: CACNA2D3
CACNA2D3
0.010 Biomarker disease BEFREE These data revealed that CACNA2D3 functions as a tumor suppressor in EC. 31746409 2020
Entrez Id: 11065
Gene Symbol: UBE2C
UBE2C
0.010 Biomarker disease BEFREE UBE2C knockdown inhibited EC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT), whereas UBE2C overexpression exerted the opposite effects. 31662448 2020
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.010 Biomarker disease BEFREE Deep and Durable Response With Combination CTLA-4 and PD-1 Blockade in Mismatch Repair (MMR)-proficient Endometrial Cancer. 30247204 2020
Entrez Id: 407018
Gene Symbol: MIR27A
MIR27A
0.010 Biomarker disease BEFREE The role of miR-27a-5p in EC migration and invasion was further investigated via transfection with miR-27a-5p mimics or inhibitor in Ishikawa and HEC-1A EC cell lines. 31710594 2020
Entrez Id: 9037
Gene Symbol: SEMA5A
SEMA5A
0.010 AlteredExpression disease BEFREE The aim of the study was to determine the changes in SEMA5A expression in endometrial cancer compared to normal endometrium and to indicate the potential use of SEMA5A as a molecular marker. 31544715 2020
Entrez Id: 406993
Gene Symbol: MIR211
MIR211
0.010 Biomarker disease BEFREE Notably, based on this network, it was found that LINC00261-hsa-mir-31 pair and LINC00261-hsa-mir-211 target pairs could be used as the potential prognostic markers of EC. 31692050 2020
Entrez Id: 4192
Gene Symbol: MDK
MDK
0.010 Biomarker disease BEFREE We also discuss the possible relationship between metformin and MK in the context of EC, the most common gynecological cancer worldwide, which incidence is rising rapidly, in parallel with the increase in obesity, T2DM and insulin resistance. 31634770 2020
Entrez Id: 7919
Gene Symbol: DDX39B
DDX39B
0.010 Biomarker disease BEFREE We think that it would be useful to determine the diagnosis, prediction of prognosis and identifying therapeutic targets of the highlighted proteins of our study that are K2C8, UAP56, GRP78 and CALR in endometrial cancer. 31783195 2020
Entrez Id: 57556
Gene Symbol: SEMA6A
SEMA6A
0.010 Biomarker disease BEFREE All in all, our research was the first endeavor to study the underlying mechanism of CHL1-AS1 in EC and confirmed that CHL1-AS1 regulated EC progression via targeting the miR-6076/CHL1 axis, offering new insight into treating EC. 31736153 2020
Entrez Id: 110806263
Gene Symbol: LOC110806263
LOC110806263
0.010 GeneticVariation disease BEFREE The TERT promoter mutations were most frequently present in bladder cancer (68.6%), followed by central nervous system tumors (28.7%), thyroid cancer (15.4%), prostate cancer (9.3%), endometrial carcinoma (3.7%), rhabdomyosarcoma (1.4%), colorectal cancer (1%), epithelial ovarian carcinoma (0.7%) and breast cancer (0.7%). 31669704 2020
Entrez Id: 2235
Gene Symbol: FECH
FECH
0.010 Biomarker disease BEFREE Knockdown of ferrochelatase (FECH) in human endometrial cancer xenografts in nude mice was performed by transfection with FECH-siRNA mediated by PEI and ultrasound microbubbles alone or in combination; then, low-dose ALA was injected. 30582757 2019
Entrez Id: 64115
Gene Symbol: VSIR
VSIR
0.010 AlteredExpression disease BEFREE Upregulation of VISTA in endometrial cancer was related to the methylation status of the VISTA promoter. 30382166 2019
Entrez Id: 213
Gene Symbol: ALB
ALB
0.010 Biomarker disease BEFREE After adjusting for confounders, postmenopausal patients had higher total serum calcium (p=0.002) and albumin-corrected serum calcium (p=0.012) than premenopausal patients, endometrioid endometrial carcinoma (EEC) patients had higher total serum calcium than non-endometrioid endometrial carcinoma (NEEC) patients (p=0.037). 30479096 2019
Entrez Id: 6694
Gene Symbol: SPP2
SPP2
0.010 GeneticVariation disease BEFREE In addition, SPP1 and SPP2 mutations mainly occurred in cutaneous melanoma and endometrial cancer. 31849319 2019
Entrez Id: 2072
Gene Symbol: ERCC4
ERCC4
0.010 Biomarker disease BEFREE In addition, we identified 2 patients who had a deleterious germline mutation in Lynch syndrome genes (MLH1 and MLH2), and another 8 patients harbored germline mutations of 6 non-Lynch syndrome genes (MUTYH, GALNT12, POLE, MPL, ATM, and ERCC4) which may be associated with endometrial cancer. 30886832 2019
Entrez Id: 25816
Gene Symbol: TNFAIP8
TNFAIP8
0.010 GeneticVariation disease BEFREE The minor allele of rs1045242 in the TNFAIP8 gene was strongly associated with with EC risk (adjust OR: 1.636, 95% CI 1.107-2.417, P = 0.014). rs11064 SNPs correlated with TNFAIP8 protein expression in EC (P = 0.015). 31043860 2019
Entrez Id: 6434
Gene Symbol: TRA2B
TRA2B
0.010 Biomarker disease BEFREE Among the dysregulated genes, the strongly upregulated TRA2B in the tissues and serum from patients with EC was selected for further analysis. 31452736 2019
Entrez Id: 12
Gene Symbol: SERPINA3
SERPINA3
0.010 Biomarker disease BEFREE There was no correlation between SERPINA3 protein in endometrial cancer cells and the age range at which women experienced menopause (<i>P</i> > 0.05). 31423431 2019
Entrez Id: 3799
Gene Symbol: KIF5B
KIF5B
0.010 AlteredExpression disease BEFREE Furthermore, we identified that CCL18 derived from TAMs upregulated KIF5B expression to promote EMT via activating the PI3K/AKT/mTOR signaling pathway in endometrial cancer. 30779215 2019