Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
0.400 Biomarker disease BEFREE The expression levels of NLRP3, its inflammasome components and estrogen receptor β in endometrial cancer and paired non-tumor tissues were detected. 31695408 2019
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
0.400 AlteredExpression disease BEFREE For this purpose, we knocked down ERβ expression in two endometrial cancer cell lines, the ERα-negative/ERβ-positive line HEC-1A and the ERα/β-positive cell line RL95/2, by means of siRNA transfection. 31357971 2019
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
0.400 AlteredExpression disease BEFREE Role of metformin in inhibiting estrogen-induced proliferation and regulating ERα and ERβ expression in human endometrial cancer cells. 29085506 2017
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
0.400 AlteredExpression disease BEFREE Our previous study in non-siRNA treated HHUA cells, which are derived from an endometrial cancer and express estrogen receptor β, showed enhancing effects of an upstream ERE on adenovirus-mediated p53 gene transduction. 26745067 2015
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
0.400 Biomarker disease BEFREE However, the conduct of studies of endometrial ERβ expression needs to be standardized: agreement is needed regarding the most appropriate control tissue for endometrial cancer studies as well as development of standardized methods for the quantification of ERβ immunohistochemical data, similar to those scoring systems employed for other hormonally regulated tissues such as breast cancer, since these data may have direct clinical implications in guiding therapy. 25305176 2015
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
0.400 Biomarker disease CTD_human To characterize model cell lines of endometrial cancer, we determined the expression profiles of the estrogen receptors (ERs) ESR1, ESR2 and GPER, and 23 estrogen biosynthetic and metabolic genes, and investigated estrogen biosynthesis in the control HIEEC cell line and the Ishikawa and HEC-1A EC cell lines. 25437045 2015
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
0.400 GeneticVariation disease BEFREE Our data clearly suggest that the tested SNPs in the promotor region of human ESR2 gene are not associated with the development of endometrial cancer. 23974281 2014
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
0.400 AlteredExpression disease BEFREE ERα and ERβ showed significantly decreased mRNA and protein expression levels in endometrial carcinoma as compared to normal endometrium. 23873111 2013
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
0.400 AlteredExpression disease BEFREE In addition, siRNA-triggered knockdown of ERβ expression led to a significant decline of MYBL2 mRNA and protein levels in endometrial cancer cells. 22378275 2012
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
0.400 GeneticVariation disease BEFREE Over-representation of ESR1 and ESR2 polymorphisms in the endometrial cancer population compared with the control population indicates an involvement in the development and/or progression of disease. 19438492 2009
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
0.400 GeneticVariation disease BEFREE Our results indicate that ESR2 polymorphisms may not be associated with endometrial cancer risk. 15280642 2004
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
0.400 AlteredExpression disease BEFREE Western blotting analysis showed that ER-beta proteins were highly expressed in comparison with ER-alpha proteins in endometrial cancer with severe myometrial invasion. 11207052 2001
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
0.400 AlteredExpression disease BEFREE Role of DNA ploidy and ERB-B2 oncogene expression in the prognosis of endometrial carcinoma. 7746737 1994