Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.800 Biomarker disease BEFREE Unusual staining patterns such as heterogeneous MSH6 staining have been reported in colorectal and endometrial cancers. 31783044 2020
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.800 Biomarker disease BEFREE Immunohistochemistry (IHC) for DNA mismatch repair proteins MLH1, PMS2, MSH2, and MSH6 is used for microsatellite instability (MSI) screening in colorectal carcinoma (CRC) and endometrial carcinoma (EC). 31402167 2020
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.800 GeneticVariation disease BEFREE Pathogenic MSH6 variants caused a sex-limited trait with high endometrial cancer risk but only modestly increased colorectal cancer risk in both genders. 31337882 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE PTEN immunohistochemical loss, a common event in endometrioid-type endometrial carcinoma and associated with local immune suppression in melanoma, was not associated with PD-L1 expression or lymphocyte/macrophage infiltration of the tumor. 30291344 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE Pilot investigation of the mutation profile of PIK3CA/PTEN genes (PI3K pathway) in grade 3 endometrial cancer. 30569174 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE PTEN loss in EH was significantly associated with increased risk of EC (OR = 3.32, p = 0.001). 30915635 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE The Relationship between the Methylation of Promoter Regions of Tumor Suppressor Genes PTEN and APC with Endometrial Cancer. 31450893 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE Evaluation of PTEN and CD4+FOXP3+ T cell expressions as diagnostic and predictive factors in endometrial cancer: A case control study. 31348233 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE Adding PTEN/TP53 mutation testing to BHLHE22/CDO1-based methylation testing did not improve the detection of endometrial cancer. 31779688 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE The most frequently altered gene in endometrioid endometrial carcinoma tumors is PTEN. 30765787 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE Besides, overexpression of PTEN markedly promoted the apoptosis of E2-induced RL95-2 cells through regulating the Bax and Bcl-2 expression, and modulated the expression of AKT pathway, p53 and Cyclin D. In conclusion, our findings revealed that miR-181c affected the estrogen-dependent endometrial carcinoma cell growth by targeting PTEN. 30971627 2019
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.800 Biomarker disease BEFREE Overall, 15% (7/50) of microsatellite instability high endometrial carcinomas showed isolated loss of MSH6 in contrast to 7% (1/15) seen in microsatellite instability high colorectal carcinomas. 30443012 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE This study aimed to determine the in vitro and in vivo properties of sixteen frequently used endometrial cancer (EC) cell lines, including the cell proliferation rate, morphology, hormone receptor expression patterns, PTEN, hMLH1 expression, p53 mutation, karyotype, and tumorigenicity in mouse xenograt model. 30107158 2019
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.800 GeneticVariation disease BEFREE The three pathogenic variants included two colorectal cancers with MLH1 loss and high MSI and one endometrial cancer with MSH6 loss and microsatellite stability. 31386297 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE Prolactin-PRLR signaling may play a crucial role for the progression of type I EC without involving the PTEN mutation in young hyperprolactinemic women without insulin resistance. 29901521 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE The aim of the present study was to evaluate the combination and individual expression of p53 and phosphatase and tensin homolog (PTEN) protein in human endometrial carcinoma. 30944646 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Furthermore, HOTAIR activated the PI3K/Akt pathway to promote EC progression by suppressing PTEN <i>in vivo</i> Taking these results together, we revealed that high expression of HOTAIR promoted cell proliferation and inhibited apoptosis through activating the PI3K/Akt pathway via binding to PTEN, which might provide a prognostic marker and therapeutic target of EC. 31527078 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE We investigated the effects of ABTL0812 on proliferation, cell death and modulation of intracellular signaling pathways in a wide panel of endometrioid and non-endometrioid cell lines, an inducible PTEN knock-out murine model, and two patient-derived xenograft murine models of EC. 30853360 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Studies in cell cultures have demonstrated that histone deacetylase inhibitors exert their antineoplastic activity by promoting expression of p21WAF1 and p27KIP1, cyclin-dependent kinase inhibitors, that have important roles in cell cycle regulation; importantly, the transcription of specific genes (e.g., E-cadherin, PTEN) that are commonly silenced in endometrial cancer is also enhanced. 29509243 2018
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.800 Biomarker disease BEFREE Lynch syndrome due to pathogenic variants in the DNA mismatch repair genes MLH1, MSH2, and MSH6 is predominantly associated with colorectal and endometrial cancer, although extracolonic cancers have been described within the Lynch tumor spectrum. 30161022 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE 13 EC cell lines were profiled for their PI3K pathway and KRAS mutational and PTEN protein status and treated with one MEK- and two PI3K- targeted inhibitors alone and in combination. 29426295 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE It is well-known that estrogen plays an important role in the pathogenesis of endometrioid endometrial carcinoma (EEC), and induces the cancer suppressor gene PTEN deletion. 30584245 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Further experiments demonstrated that the expression levels of PTEN and phosphorylated-AKT in HEC-1B and Ishikawa endometrial cancer cells was decreased and increased, respectively, following aberrant expression of miR-423. miR-423 displayed an important role in tumorigenesis and progression in endometrial cancer cells, and may therefore be used as a potential biomarker to predict chemotherapy response and prognosis in endometrial cancer. 30344696 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Together, these results suggest PI3K inhibition may be a plausible approach to expand the utility of PARP inhibitors to endometrioid endometrial cancers in a PTEN-deficient setting. 28945226 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE The aim of this study was to investigate the prognostic value of the Hedgehog (Gli, Patched-1, Shh, Smo) and Notch (Jag1, Notch2, Notch3) pathway members, in comparison to a panel of proteins (ER, PgR, HER2/neu, Ki67, p53, p16, PTEN and MMR) previously suggested to be involved in the pathogenesis of endometrial cancer, in association with clinical outcome and standard clinicopathological characteristics. 30521558 2018