Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.800 GeneticVariation disease BEFREE Analysis of the MMR genes, in particular MSH6, seems to be appropriate in women with endometrial cancer and a family history of tumours associated with LS. 27398995 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE The tumor suppressor gene TP53 is mutated exclusively with the HYDIN, KRAS, and PTEN genes in large intestine, lung, and endometrial cancers respectively, indicating that TP53 takes part in different signaling pathways in different cancers. 26212640 2016
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.800 PosttranslationalModification disease BEFREE We analyzed immunohistochemistry of MMR proteins (MLH1/MSH2/MSH6/PMS2) and MLH1 promoter methylation in primary endometrial carcinomas from 221 consecutive patients. 26644264 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE CCNE1 amplification was independent of p53, HER2, MLH1 and ARID1A expression but dependent on PTEN expression in endometrial carcinomas. 26647729 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Loss of PTEN function has been detected frequently in different forms of cancers, such as breast, prostate and lung cancer, gastric and colon cancer, skin cancer, as well as endometrial carcinoma. 25773992 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE PTEN expression in benign human endometrial tissue and cancer in relation to endometrial cancer risk factors. 26376893 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE We identified a high frequency of mutations in PTEN (50%) and genes involved in the endometrial cancer-related molecular pathway, which involves the IL-7 signaling pathway (PIK3R1, n=1; AKT2, n=1; FOXO1, n=1). 26626801 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE While most were previously reported in CRC, one mutation in PTEN was reported only in malignant endometrium cancer. 25617745 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE Up-regulation of genes involved in the insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link polycystic ovarian syndrome and endometrial cancer. 26802879 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE PTEN sequence analysis in endometrial hyperplasia and endometrial carcinoma in Slovak women. 26114084 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Modeling glands with PTEN deficient cells and microscopic methods for assessing PTEN loss: endometrial cancer as a model. 25461816 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE LncRNA-GAS5 induces PTEN expression through inhibiting miR-103 in endometrial cancer cells. 26511107 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE MiR-205 inhibits cell apoptosis by targeting phosphatase and tensin homolog deleted on chromosome ten in endometrial cancer Ishikawa cells. 24929707 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Evidence for different expression profiles for c-Met, EGFR, PTEN and the mTOR pathway in low and high grade endometrial carcinomas in a cohort of consecutive women. Occurrence of PIK3CA and K-Ras mutations and microsatellite instability. 24811063 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 PosttranslationalModification disease BEFREE Rapid estrogen signaling negatively regulates PTEN activity through phosphorylation in endometrial cancer cells. 24844349 2015
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.800 CausalMutation disease CLINVAR Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. 25741868 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE 4-hydroxy estrogen induces DNA damage on codon 130/131 of PTEN in endometrial carcinoma cells. 25449419 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE FISH analysis of PTEN in endometrial carcinoma. Comparison with SNP arrays and MLPA. 25353038 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE We also report that nuclear localization of FOXO1 correlated with PTEN mutational status irrespective of the PIK3CA status in endometrial cancer cell lines. 25698082 2015
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.800 AlteredExpression disease BEFREE Endometrial cancers from 173 patients recruited to the Nanchong Central Hospital were tested for MMR (MLH1, MSH2, PMS2, and MSH6) protein expression using immunohistochemistry (IHC). 25400828 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE Piwil1 causes epigenetic alteration of PTEN gene via upregulation of DNA methyltransferase in type I endometrial cancer. 26056945 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE miR-200a, miR-200b and miR-429 are onco-miRs that target the PTEN gene in endometrioid endometrial carcinoma. 25750291 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE Association of specific PTEN/10q haplotypes with endometrial cancer phenotypes in African-American and European American women. 26026735 2015
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.800 Biomarker disease BEFREE Heterogenous MSH6 loss is a result of microsatellite instability within MSH6 and occurs in sporadic and hereditary colorectal and endometrial carcinomas. 26099011 2015
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
0.800 Biomarker disease BEFREE In this study, we investigated the frequency of BAF250a immunohistochemical loss in a cohort of high-grade endometrial cancers (n=190) and correlated it with mismatch repair (hMLH1, hMSH2, hMSH6, and hPMS2) and p53 protein expression. 23887303 2014