Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.390 Biomarker disease BEFREE Additional studies are needed to confirm the usefulness of BACE1, alone or in combination with other markers, in discriminating patients and predicting LOAD onset and progression. 31745860 2020
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.390 GeneticVariation disease BEFREE Abbreviations: Alzheimer's disease (AD); Late-onset Alzheimer's disease (LOAD); Early-onset Alzheimer's disease (EOAD); Shugoshin-1 (Sgo1); Chromosome Instability (CIN); apolipoprotein (Apoe); Central nervous system (CNS); Amyloid precursor protein (APP); N-methyl-d-aspartate (NMDA); Hazard ratio (HR); Cyclin-dependent kinase (CDK); Chronic Atrial Intestinal Dysrhythmia (CAID); beta-secretase 1 (BACE); phosphor-Histone H3 (p-H3); Research and development (R&D); Non-steroidal anti-inflammatory drugs (NSAIDs); Brain blood barrier (BBB). 30231670 2018
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.390 AlteredExpression disease BEFREE Our findings provide a mechanistic role of BIN1 in the pathogenesis of AD as a novel genetic regulator of BACE1 levels and Aβ production. 27179792 2016
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.390 Biomarker disease BEFREE We collected blood DNA from 120 late-onset Alzheimer's disease (AD) patients and 115 healthy matched controls and analysed the methylation levels of genes involved in amyloid-beta peptide production (PSEN1 and BACE1), in DNA methylation (DNMT1, DNMT3A and DNMT3B), and in one-carbon metabolism (MTHFR), searching for correlation with age and gender, with biomarkers of one-carbon metabolism (plasma homocysteine, and serum folate and vitamin B12 levels), and with disease status (being healthy or having AD). 26079324 2015
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.390 GeneticVariation disease BEFREE LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD). 23750206 2013
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.390 Biomarker disease BEFREE LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease. 17098871 2006
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.390 Biomarker disease CTD_human Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. 16407166 2006
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.390 GeneticVariation disease BEFREE These results suggest that BACE1 gene polymorphism C786G might act as an APOE epsilon4 allele-dependent risk factor for developing LOAD in Chinese. 15784960 2005
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.390 GeneticVariation disease BEFREE Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriers. 12707937 2003
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.390 Biomarker disease BEFREE The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease. 11234778 2001