Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 GeneticVariation disease BEFREE In contrast, peptides deriving from microtubule-associated protein tau, presenilin 2 and serine/threonine-protein kinase TBK1 were exclusively reported to bind MHC molecules encoded by the HLA-DRB1 1501 allele, a recently-identified susceptibility gene for late onset Alzheimer's disease. 31824497 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 GeneticVariation disease BEFREE The majority of up-to-date epigenomic findings include reported modifications in the well-known LOAD core pathology loci MAPT, BACE1, APP (with FOS, EGR1), PSEN1, PSEN2, and highlight a central role of BDNF. 30386171 2018
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker disease BEFREE The hallmark pathology of AD consists of pathological aggregates of amyloid-β (Aβ) peptides and tau proteins. 27829172 2017
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 GeneticVariation disease BEFREE MAPT H1 Haplotype is Associated with Late-Onset Alzheimer's Disease Risk in APOEɛ4 Noncarriers: Results from the Dementia Genetics Spanish Consortium. 26444794 2016
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker disease CTD_human The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease. 27117003 2016
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker disease CTD_human Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis. 25352456 2015
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 PosttranslationalModification disease BEFREE We measured MAPT promoter methylation in a brain tissue cohort of early-onset Alzheimer's disease (EOAD) with defined causative mutations in the PSEN1 gene (Normal = 10, PSEN1 AD = 10), and idiopathic late-onset Alzheimer's disease (Normal = 12, LOAD = 12). 26159201 2015
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker disease BEFREE Late-onset Alzheimer's Disease (LOAD) is a common neurodegenerative disease [1], and the two well identified pathological hallmarks of LOAD are senile plaques formed from amyloid β peptides (Aβ) and neurofibrillary tangles (NFTs) consisting of hyperphorylated tau protein [2]. 24309291 2014
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker disease BEFREE The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. 22027014 2012
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 GeneticVariation disease BEFREE In addition, a synergistic effect of polymorphisms in ApoE ε4 and Tau gene STR loci rs5820604 (CA)(19) allele was found in the pathogenesis of AD (p = .025, OR [odds ratio] = 3.178, 95% CI [confidence interval] = 1.156-8.741). 22176350 2012
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 GeneticVariation disease BEFREE To determine whether polymorphisms in the GSK3B gene and microtubule associated protein tau (MAPT) gene underpin susceptibility to late-onset Alzheimer's disease (LOAD), we conducted a case-control study in a Chinese cohort of 257 LOAD cases and 326 healthy controls matched for sex and age. 21443865 2011
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker disease CTD_human Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation. 21715663 2011
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker disease CTD_human Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. 20157255 2010
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker disease BEFREE However, numerous association studies investigating the genetic involvement of MAPT in LOAD have generated conflicting results. 19308965 2009
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 GeneticVariation disease BEFREE We failed to detect evidence of association of the H1c haplotype at the MAPT locus with LOAD. 17266761 2007
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker disease CTD_human Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? 15750215 2005
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker disease CTD_human Tau (MAPT) mutation Arg406Trp presenting clinically with Alzheimer disease does not share a common founder in Western Europe. 14517953 2003
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker disease CTD_human Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation. 12852432 2003