Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE Our results, suggest that a p.(Gly145Trp)-induced structural disturbance and functional impairment of TREM2 may contribute to the pathogenesis of an AD-like form of dementia. 31464095 2020
Entrez Id: 351
Gene Symbol: APP
APP
0.700 AlteredExpression disease BEFREE Moreover, as activation of δ-opioid receptor by a non-peptidic δ-opioid receptor agonist also modulates the expression, maturation and processing of amyloid precursor protein and β-secretase activity, the potential role of these effects on ischemic stroke caused dementia or Alzheimer's disease are also discussed. 31535637 2020
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE A novel homozygous mutation in TREM2 found in a Chinese early-onset dementia family with mild bone involvement. 30797549 2020
Entrez Id: 351
Gene Symbol: APP
APP
0.700 Biomarker disease BEFREE The purpose of this study was to examine the association between cognitive function and several serum miRNAs levels related to amyloid precursor protein (APP) proteolysis in a Japanese general population who had never been diagnosed with dementia. 30802839 2020
Entrez Id: 351
Gene Symbol: APP
APP
0.700 Biomarker disease BEFREE Cystatin isolated from chicken egg white, called ovocystatin, has been widely used in the medical and pharmaceutical research due to its structural and biological similarities to human cystatin C. The aim of this study was to assess the effect of administering ovocystatin on the development of dementia-specific cognitive deficits in APP/PS1 transgenic mice. 30504006 2019
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE Recently, soluble fragments of the triggering receptor expressed on myeloid cells 2 (sTREM2) protein in CSF have been reported to be increased in prodromal AD and also in individuals with TREM2 rare genetic variants that increase the likelihood of developing dementia. 31779670 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.700 GeneticVariation disease BEFREE 2) Family members with codon 717 APP mutations and dementia have low serum vitamin B12 values. 30814347 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.700 GeneticVariation disease BEFREE Amyloid PET pattern with dementia and amyloid angiopathy in Taiwan familial AD with D678H APP mutation. 30703749 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.700 Biomarker disease BEFREE The evidence that a pathogenic APP mutation causes an early enhancement of BAD-Glu suggests that alterations of BACE1 processing of APP in glutamatergic synaptic vesicles could contribute to dementia. 31496118 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.700 Biomarker disease BEFREE Therefore, we exposed an AD-relevant mouse model (APP/PS1 KI) to chronic intermittent hypoxia (IH) (an experimental model of sleep apnea) to begin to describe one of the potential mechanisms by which SDB could increase the risk of dementia. 30529693 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.700 Biomarker disease BEFREE Also problematic is the alternative hypothesis that, instead of amyloid plaques, it is oligomers of amyloid precursor protein that cause AD.Evidence is presented suggesting amyloid/oligomers as necessary but insufficient causes of the dementia and that, for dementia to develop, requires the addition of cofactors known to be associated with AD. 28509380 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.700 GeneticVariation disease BEFREE We review current knowledge on clinical diagnosis and presentation of dementia in DS in comparison with FAD due to APP mutations and APP duplication. 28870521 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 Biomarker disease BEFREE Triggering receptor expressed on myeloid cells 2 (TREM2) is linked to dementia and neurodegenerative disease. 30390679 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.700 AlteredExpression disease BEFREE We explored how levels of endocytic proteins, APP, its metabolites, secretase enzymes, and tau varied with age in cortical brain samples from men of three age ranges (young [20-30], middle aged [45-55], and old [70-90]) with no symptoms of dementia. 28655199 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.700 Biomarker disease BEFREE Neuropsychiatric symptoms have been reported as prodromal symptoms of AD-like dementia and soluble forms of beta amyloid peptide (), the main constituent of insoluble plaques typical of AD brains, have been implicated in such an effect. 29879605 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 Biomarker disease BEFREE The triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial innate immune receptor associated with a lethal form of early, progressive dementia, Nasu-Hakola disease, and with an increased risk of Alzheimer's disease. 29752066 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.700 Biomarker disease BEFREE Scrutiny of the evidence generated so far reveals and a lack of understanding of the wider APP proteolytic system and how narrow research into the dementia syndrome has been to date. 30246866 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE TREM2 variant carriers showed a 23% faster rate of dementia compared with non-variant carriers. 29480181 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.700 Biomarker disease BEFREE We used immunoassays to measure conventional CSF markers of amyloid and tau pathology (amyloid beta (Aβ)1-42, total tau (T-tau), and phosphorylated tau (P-tau)) as well as amyloid processing (AβX-38, AβX-40, AβX-42, soluble amyloid precursor protein (sAPP)α, and sAPPβ), large fibre axonal degeneration (neurofilament light chain (NFL)), and neuroinflammation (YKL-40) in 245 patients with a variety of dementias and 30 controls. 29558979 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.700 Biomarker disease BEFREE APP is involved in the pathology of Alzheimer's disease (AD), the most common neurodegenerative disorder causing dementia. 29383688 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.700 GeneticVariation disease BEFREE We attempted to evaluate the mutation burden in genes encoding amyloid precursor protein metabolism and previously linked to risk of dementias. 29329714 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 Biomarker disease BEFREE We reveal an unexpected potential role of Trem2 in the homeostasis of endothelial cells that goes beyond its known functions as a microglial receptor and signaling hub, suggesting an underlying link between immune response and vascular disease in dementia. 29906661 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.700 Biomarker disease BEFREE BACE1 activity and sAβPPβ concentration were measured in patients with AD dementia (n = 56) and mild cognitive impairment (MCI) due to AD (n = 76) with abnormal routine AD CSF markers, in patients with MCI with normal CSF markers (n = 39), and in controls without preclinical AD (n = 48). 29788013 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 GeneticVariation disease BEFREE Loss-of-function mutations in TREM2 cause Nasu-Hakola disease (NHD), a rare genetic disease characterized by early-onset dementia with leukoencephalopathy and bone cysts. 29720600 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
0.700 Biomarker disease BEFREE Plasma membrane receptors play primary roles as activators of microglia and in this review, we focus on a receptor complex involving triggering receptor expressed on myeloid cells 2 (TREM2) and DNAX-activating protein of 12 kDa (DAP12), both of which are causative genes for Nasu-Hakola disease, a dementia with bone cysts. 30127720 2018