Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE Berberine chloride ameliorated PI3K/Akt-p/SIRT-1/PTEN signaling pathway in insulin resistance syndrome induced in rats. 31512260 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE Our results indicate that activation of the miR-34a/SIRT1:AMPK pathway leads to mitochondrial dynamics dysfunction in skeletal muscle of human and experimental NAFLD, representing an appealing prospective target in metabolic syndrome. 31139863 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE Finally, we demonstrated that EF-sir2 could significantly improve the metabolic index of mammalian cells through insulin resistanced model in vitro and metabolic syndrome rat model in vivo. 30512225 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE The NAD<sup>+</sup>-dependent deacetylase SIRT1, which is associated with the improvement of metabolic syndromes, such as type 2 diabetes, is a well-known longevity-related gene. 29402742 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE SIRT1, for example, protects against a decline in vascular endothelial function, metabolic syndrome, ischemia-reperfusion injury, obesity, and cardiomyopathy, and SIRT3 is protective against dyslipidemia and ischemia-reperfusion injury. 30355082 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE Taken together, these findings indicate that IGFBP-2 might be a new target of metformin action in diabetes and the metformin-AMPK-Sirt1-PPARα-IGFBP-2 network may provide a novel pathway that could be applied to ameliorate metabolic syndromes by controlling IGF-1 bioavailability. 27009398 2016
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease RGD Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity. 25356430 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE These results indicate that glutathione adducts on specific SirT1 thiols may be responsible for dysfunctional SirT1 associated with liver disease in metabolic syndrome. 24451382 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 AlteredExpression disease BEFREE HuR expression and binding to SIRT1 were also analysed ex vivo in peripheral blood mononuclear cells (PBMCs) of subjects with and without the metabolic syndrome (MS), by immunoprecipitation (IP) of the ribonucleoprotein (RNP) complex. 24702436 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 GeneticVariation disease BEFREE Age-related MS and diabetes are also causally associated with suppressed SIRT1 partly due to oxidant glycotoxins [advanced glycation end products (AGEs)]. 24567379 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE SIRT1 in metabolic syndrome: where to target matters. 22939883 2012
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Therapeutic disease RGD To determine the effects of food restriction (FR) on the expression of Sirt1 and its down-stream factors related to lipid and glucose metabolism in obese and hypertensive rats (SHRSP/IDmcr-fa), as a model of human metabolic syndrome. 21514307 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 AlteredExpression disease BEFREE In vivo, insulin resistance and metabolic syndrome were associated with low PBMC SIRT1 gene and protein expression. 20068143 2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease CTD_human In vivo, insulin resistance and metabolic syndrome were associated with low PBMC SIRT1 gene and protein expression. 20068143 2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 GeneticVariation disease BEFREE Nominally significant associations were also observed between T2D and the SIRT1 rs3758391 SNP and MS and the HHEX rs5015480 polymorphism. 20503258 2010
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE These findings suggest that SIRT1 might be a new therapeutic target for the prevention of disease related to insulin resistance, such as metabolic syndrome and diabetes mellitus, although direct evidence from clinical studies in humans is needed to prove this possibility. 19455179 2009