Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.600 Biomarker disease BEFREE Interleukin-18 (IL-18) is a proinflammatory cytokine associated with metabolic syndrome (MS). 29854715 2018
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.600 Biomarker disease BEFREE Inflammasomes, which are intracellular multi-protein complexes, promote acute and chronic inflammation via interleukin-1β or interleukin-18 maturation, and they are known targets for metabolic syndromes and cancer. 27133472 2018
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.600 Biomarker disease BEFREE Conversely, a non-significant increase in IL-18 was observed in the MetS and MetS pre/T2DM groups compared to normoglycaemic lean controls (232 and 287.5, <i>p</i> > 0.05 versus 108 for both). 30515292 2018
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.600 Biomarker disease BEFREE Interleukin-18 (IL-18) is an inflammatory cytokine found to be elevated in obesity, metabolic syndrome and type 2 diabetes (T2D) as a part of the chronic low-grade inflammatory process in these states. 29217651 2018
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.600 Biomarker disease BEFREE The control group consisted of 33 men without MS and low T. IL-18 was determined in serum using enzyme-linked immunosorbent assay. 29168426 2018
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.600 Biomarker disease BEFREE Susceptibility disorders for AD, including obesity, type-2 diabetes, cardiovascular diseases and metabolic syndrome have been linked to increases in the proinflammatory cytokine, IL-18, which also regulates multiple AD related proteins. 28531131 2017
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.600 Therapeutic disease RGD Betaine supplementation protects against high-fructose-induced renal injury in rats. 24456735 2014
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.600 AlteredExpression disease BEFREE Multivariate analysis revealed fasting plasma glucose to be the only MetS component being independently associated with expression of IL-18 in AT (p < 0.05). 21842238 2011
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.600 AlteredExpression disease BEFREE IL-18 levels were significantly higher in men as compared to women, and in patients with diabetes type 2 and metabolic syndrome compared to those without (p ≤ 0.001, all). 22141572 2011
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.600 GeneticVariation disease BEFREE We investigated variation within the IL18 gene and its association with measures of obesity and the metabolic syndrome. 20227263 2011
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.600 Biomarker disease RGD Targeting expression of IL-18 or its specific downstream mediators may retard the progression of MetS and its complications. 19717152 2010
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.600 GeneticVariation disease BEFREE We investigated variation within the IL18 gene and its effect on markers of the metabolic syndrome. 17445542 2007
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.600 Biomarker disease CTD_human Effect of rosiglitazone on endothelial function and inflammatory markers in patients with the metabolic syndrome. 16644639 2006