Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
0.340 Biomarker disease BEFREE Pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is a crucial regulator of nutrient metabolism and metabolic detoxification such as metabolic syndrome, xenobiotic metabolism, inflammatory responses, glucose, cholesterol and lipid metabolism, and endocrine homeostasis. 28534176 2017
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
0.340 Biomarker disease BEFREE Chronic exposure to PXR agonists could potentially represent a risk factor for diabetes and metabolic syndrome. 27041449 2016
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
0.340 Biomarker disease BEFREE Together, these studies indicate that the hPXR gene promotes obesity and metabolic syndrome by dysregulating lipid and glucose homeostasis while inhibiting UCP1 expression. 24721462 2014
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
0.340 Biomarker disease BEFREE Altogether, although the mouse PXR promotes HFD-induced obesity, the hPXR mouse carries a genetic predisposition for type 2 diabetes and thus provides a model for exploring the role of human PXR in the metabolic syndrome. 24362030 2014
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
0.340 Biomarker disease CTD_human CAR and PXR are involved in the development of certain diseases, including diabetes, metabolic syndrome and obesity. 20869355 2010