Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 Biomarker disease BEFREE We demonstrated previously that offspring born to pregnant mice lacking the endothelial nitric oxide synthase (eNOS+/-) gene have hypertension (HTN) as adults and, when fed a high-fat diet (HFD), develop a metabolic syndrome (MS) phenotype. 30521799 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE Leptin promotes adequate caloric intake and glycemia in healthy lean individuals, harnessing the benefits of the ideal therapy against metabolic syndrome. 30792083 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE A Receiver Operator Characteristic curve was used to identify the ability of adiponectin and leptin level to predict the MetS. 31341853 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE The adipokines DPP-4 and leptin in the serum can influence the body fat distribution of patients with T2MD; there is an important association of DPP-4, leptin and ADPN levels with MS, which may be used as therapeutic targets for multiple metabolism disorders of T2MD. 29205013 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE Low vitamin D level was associated with metabolic syndrome and high leptin level in subjects with nonalcoholic fatty liver disease: a community-based study. 31311491 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE The addition of leptin and adiponectin to the regression models did not substantially change the impact of thyroid hormones on components of MS. Our data suggest that, even within the euthyroid range, excess of truncal adipose tissue is associated with variations in FT4. 31151171 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE We previously found that blood C-reactive protein (CRP), interleukin-6 (IL-6), and leptin levels were predictors of current metabolic syndrome in schizophrenia. 31118157 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE Adiponectin, leptin and hs-CRP were significantly modified in the group with MetS (p=0.04, p=0.04, p=0.01, respectively). 30530892 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE The 8-week individualized training program decreased glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol and leptin in obese subjects with and without MS. 30832279 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE We aimed to explore the association of <i>LEPR</i> polymorphisms with obesity, metabolic syndrome (MetS), and leptin levels in Afro-Caribbean nondiabetic subjects. 30807250 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE Obesity and the MS are distinguished by an increase in circulating leptin concentrations, in parallel to a drop in the levels of adiponectin. 30813240 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE The aim of this study was to determine whether MetS has an impact on the global DNA methylation pattern and the DNA methylation of several genes related to adipogenesis (PPARG, PPARA), lipid metabolism (RXRA, SREBF2, SREBF1, SCD, LPL, LXRb), and inflammation (LRP1 C3, LEP and TNF) in visceral adipose tissue. 30642114 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE Berberine chloride ameliorated PI3K/Akt-p/SIRT-1/PTEN signaling pathway in insulin resistance syndrome induced in rats. 31512260 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE Moreover, the circulating miRNA profiles were associated with the plasma leptin level in metabolic syndrome, and miRNAs were found to be involved in hypothalamic leptin sensitivity. 31408957 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE Understanding the inflammatory effects of leptin on the pulmonary system provides opportunities to develop strategies against lung injury related to metabolic syndrome or obesity. 30832310 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE This review provides an updated 'state-of-the-art' about the leptin and its role in the pathophysiology of metabolic syndrome at the molecular level. 31154250 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE Our results indicate that activation of the miR-34a/SIRT1:AMPK pathway leads to mitochondrial dynamics dysfunction in skeletal muscle of human and experimental NAFLD, representing an appealing prospective target in metabolic syndrome. 31139863 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE The synovium and IPFP in the MetS-OA group secreted more leptin and less adiponectin than those in the non-MetS-OA group (Leptin: 5.32 vs. 1.28 in synovium, respectively; <i>p</i>= 0.028; 6.44 vs. 0.88 in IPFP, respectively; <i>p</i>= 0.017. 31137976 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE <b>Conclusions:</b> Overall, we have found that curcumin intake among patients with metabolic syndrome and related disorders was correlated with a significant reduction in BMI, weight, WC, and leptin, and a significant increase in adiponectin levels, but did not affect HR. 31249528 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE High plasma leptin in early adulthood, a risk factor for cardio-metabolic syndrome, was associated with low weight at age two years (correlation coefficient controlled for adult weight = -0.21, p<0.01). 31661671 2019
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.600 GeneticVariation disease BEFREE The finding that metabolic syndrome is associated with worse cognition only in the presence of the eNOS-786C allele may clarify extant inconsistencies in the literature. 31421598 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE The ARR correlated with the number of variables of MetS (r = 0.191, P = 0.002), body mass index (BMI; r = 0.136, P = 0.026), systolic blood pressure (r = 0.183, P = 0.002), diastolic blood pressure (r = 0.1917, P = 0.0014), potassium excreted fraction (r = 0.174, P = 0.004), low-density lipoprotein (r = 0.156, P = 0.01), plasminogen activator inhibitor type 1 (r = 0.158, P = 0.009), microalbuminuria (r = 0.136, P = 0.029), and leptin (r = 0.142, P = 0.019). 30753255 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE Significant increases were observed in blood pressure, HOMA-IR, leptin, triglycerides, insulin, intra-abdominal fat, and number of fat cells per field (<i>p</i> = 0.001) and in advanced glycosylation products, adipocyte area, LPL, HSL activities and/or expression (<i>p</i> ≤ 0.01) in the MS groups progressively from the third month onward. 31284400 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE Linear regression confirmed an independent association of both leptin and hs-CRP with VFth in women, also after adjustment for age and MetS (<i>p</i> = 0.012 and 0.007, respectively). 31783662 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.600 Biomarker disease BEFREE Finally, we demonstrated that EF-sir2 could significantly improve the metabolic index of mammalian cells through insulin resistanced model in vitro and metabolic syndrome rat model in vivo. 30512225 2019