Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1410
Gene Symbol: CRYAB
CRYAB
0.360 Biomarker group BEFREE The small heat shock proteins, especially HspB4 and HspB5 are promising protectants in neurodegenerative diseases. 29425965 2018
Entrez Id: 1410
Gene Symbol: CRYAB
CRYAB
0.360 Biomarker group BEFREE Dysfunction of αB is closely related to cataract, and many neurodegenerative diseases including Alzheimer's, Parkinson's, and Creutzfeldt-Jakob disease. 28176658 2017
Entrez Id: 1410
Gene Symbol: CRYAB
CRYAB
0.360 Biomarker group BEFREE Although αBC has been shown to provide a protective effect in neurodegenerative diseases, inflammation, diabetes, and retinal diseases, other studies have described a deleterious role of αBC in cancers and pulmonary fibrosis. 25601468 2015
Entrez Id: 1410
Gene Symbol: CRYAB
CRYAB
0.360 Biomarker group BEFREE Alexander disease (AxD) is a neurodegenerative disorder with prominent white matter degeneration and the presence of Rosenthal fibers containing aggregates of glial fibrillary acidic protein (GFAP), and small stress proteins HSP27 and αB-crystallin, and widespread reactive gliosis. 23594359 2014
Entrez Id: 1410
Gene Symbol: CRYAB
CRYAB
0.360 GeneticVariation group BEFREE CryAB R120G causes perinuclear formation of aggresomes containing preamyloid oligomer intermediates, which are wellknown as a primary toxic species in neurodegenerative disease. 22040875 2011
Entrez Id: 1410
Gene Symbol: CRYAB
CRYAB
0.360 AlteredExpression group BEFREE The small heat shock protein αB-crystallin (HspB5) is known to be overexpressed in several neurodegenerative disorders. 20804537 2010
Entrez Id: 1410
Gene Symbol: CRYAB
CRYAB
0.360 Biomarker group CTD_human Pharmacogenomic profiling of an oxidative stress-mediated spongiform encephalopathy. 15964507 2005