| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | Biomarker | group | BEFREE | A few studies have shown that orexin A exhibits anti-inflammatory and neuroprotective properties, suggesting that it might provide therapeutic effects in inflammatory and neurodegenerative diseases like multiple sclerosis (MS). | 30894198 | 2019 | ||||
|
0.370 | GeneticVariation | group | BEFREE | Narcolepsy was first identified almost 130 years ago, but it was only 15 years ago that it was identified as a neurodegenerative disease linked to a loss of orexin neurons in the brain. | 28445807 | 2017 | ||||
|
0.370 | Biomarker | group | BEFREE | It has been shown that orexin-A has protective effects in neurodegenerative disease such as PD. | 27814668 | 2017 | ||||
|
0.370 | Biomarker | group | BEFREE | This is the first report assessing orexin immunoreactivity in Perry syndrome, and it showed significant reduction, similar to select neurodegenerative diseases, such as MSA. | 28651750 | 2017 | ||||
|
0.370 | Biomarker | group | CTD_human | Lead-induced neurodegenerative events and abnormal behaviors occur via ORXRergic/GABA(A)Rergic mechanisms in a marine teleost. | 23246865 | 2013 | ||||
|
0.370 | Biomarker | group | BEFREE | The role of orexin in a number of other domains such as pain, mood, anxiety, migraine and neurodegenerative diseases is an active area of research. | 24215799 | 2013 | ||||
|
0.370 | AlteredExpression | group | BEFREE | Narcolepsy is a neurodegenerative disorder resulting in the instability of the sleep-wake cycle and marked by low levels of hypocretin in cerebrospinal fluid. | 20426704 | 2010 | ||||
|
0.370 | Biomarker | group | BEFREE | Finally, this mini-review will also speculate on: (1) the potential importance of tyrosine-based motifs in the large family of GPCRs; (2) the interest of orexin receptors as therapeutic targets in cancer therapy; (3) the possible role of orexin receptor-mediated apoptosis in physiology and pathophysiology in the brain (neurodevelopment, neurodegenerative diseases) and in the periphery. | 19719798 | 2010 |