| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.360 | AlteredExpression | group | BEFREE | Elevation of IL-6 expression is linked to the pathogenesis of neurodegenerative diseases and astrogliosis. | 28288823 | 2017 | ||||
|
0.360 | Biomarker | group | BEFREE | In contrast to the previously reported gliogenic effects of activation of the IL-6-signal transducer and activator of transcription 3 (STAT3) axis, this review summarizes recent studies showing that IL-6 activation can be neurogenic and has potential therapeutic applications for the treatment of neurodegenerative diseases such as Parkinson's disease. | 29036854 | 2017 | ||||
|
0.360 | Biomarker | group | BEFREE | Interleukin-6 (IL-6) is a cytokine shown to affect brain function and to be involved in pathological neurodegenerative disorders such as Alzheimer's disease (AD). | 15265638 | 2004 | ||||
|
0.360 | Biomarker | group | CTD_human | Profound increase in sensitivity to glutamatergic- but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6. | 12836160 | 2003 | ||||
|
0.360 | Biomarker | group | BEFREE | Our data indicate that the IL-6 gene polymorphism is associated with AD in Italians and confirm that IL-6 is crucial in the pathophysiology of neurodegenerative disorders. | 12352619 | 2002 | ||||
|
0.360 | Biomarker | group | LHGDN | Influence of reduced nicotinamide adenine dinucleotide on the production of interleukin-6 by peripheral human blood leukocytes. | 11847482 | 2001 | ||||
|
0.360 | AlteredExpression | group | BEFREE | Specifically: (1) transgenic expression of the cytokines IL-6, IL-3 and IFN-alpha in the CNS results in the development of acute (high expression) or chronic progressive (low expression) CNS disease associated with a spectrum of clinical, physiologic and pathologic manifestations; (2) although the clinical, cellular and molecular phenotype produced by the cerebral expression of the various cytokines showed some overlap, the differences were more prominent reflecting the unique actions of each cytokine; (3) these transgenic models which recapitulate many of the structural and functional impairments seen in human neurodegenerative diseases, highlight the point that cytokines, which normally function as primary regulators of the host response, also have the potential to mediate significant injury in the CNS. | 7572281 | 1995 |