Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 GeneticVariation group BEFREE The neuromodulatory gene DISC1 is disrupted by a t(1;11) translocation that is highly penetrant for schizophrenia and affective disorders, but how this translocation affects DISC1 function is incompletely understood. 30190480 2018
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 GeneticVariation group BEFREE Disrupted-in-schizophrenia 1 (DISC1) was initially identified as a gene disrupted by a translocation mutation co-segregating with a variety of psychotic and mood disorders in a Scottish pedigree. 28664299 2017
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker group BEFREE The DISC1 gene is strongly linked to mood disorders and schizophrenia in a Scottish pedigree. 27354230 2016
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker group BEFREE We aimed to investigate whether DISC1 differentially modulates brain function during executive and memory processing, and morphology in regions relevant for depression and anxiety disorders (affective disorders). 25533973 2015
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker group PSYGENET We aimed to investigate whether DISC1 differentially modulates brain function during executive and memory processing, and morphology in regions relevant for depression and anxiety disorders (affective disorders). 25533973 2015
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker group PSYGENET Disrupted-in-Schizophrenia 1 (DISC1) is a well researched candidate gene for schizophrenia and affective disorders with a range of functions relating to neurodevelopment. 23602339 2013
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker group BEFREE We wanted to examine the role of DISC1 in ADHD, and with comorbid symptoms of mood disorders. 23389941 2013
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker group PSYGENET DISC1 is an important gene for schizophrenia and mood disorders based on both human and animal studies. 23637159 2013
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker group BEFREE Disrupted-in-Schizophrenia 1 (DISC1) is a well researched candidate gene for schizophrenia and affective disorders with a range of functions relating to neurodevelopment. 23602339 2013
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker group PSYGENET We wanted to examine the role of DISC1 in ADHD, and with comorbid symptoms of mood disorders. 23389941 2013
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker group PSYGENET A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins. 22547224 2012
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 GeneticVariation group BEFREE A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins. 22547224 2012
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 GeneticVariation group BEFREE Strong genetic evidence implicates mutations and polymorphisms in the gene Disrupted-In-Schizophrenia-1 (DISC1) as risk factors for both schizophrenia and mood disorders. 20048751 2011
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker group BEFREE Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. 19255581 2010
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker group BEFREE During the last decade, disrupted-in-schizophrenia 1 (DISC1) has emerged as a protein involved in the pathogenesis of chronic mental diseases such as schizophrenia, or recurrent affective disorders. 20397618 2009
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker group BEFREE Disrupted-in-schizophrenia 1 (DISC1) and other genes have been identified recently as potential molecular players in chronic psychiatric diseases such as affective disorders and schizophrenia. 18400883 2008
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker group BEFREE Disrupted-in-Schizophrenia-1 (DISC1) is now an important candidate risk gene for schizophrenia and affective disorders. 18474207 2008
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker group LHGDN Disrupted-in-Schizophrenia-1 (DISC1) is now an important candidate risk gene for schizophrenia and affective disorders. 18474207 2008
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 GeneticVariation group BEFREE Genetic variants of DISC1 also predispose to related affective (mood) disorders. 17258902 2007
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 GeneticVariation group BEFREE Additionally, a number of independent genetic studies highlight the region of chromosome 1q containing DISC1 and DISC2 as a likely susceptibility locus for both schizophrenia and affective disorders. 15478311 2004
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 GeneticVariation group BEFREE The results of karyotypic, clinical, and ERP investigations of this family suggest that the recently described genes DISC1 and DISC2, which are directly disrupted by the breakpoint on chromosome 1, may have a role in the development of a disease phenotype that includes schizophrenia as well as unipolar and bipolar affective disorders. 11443544 2001