Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation group BEFREE The serotonin transporter (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) gene polymorphisms have been associated with risk for affective disorders and functional variability of the amygdala. 30711709 2019
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker group CTD_human NR3C1 hypermethylation in depressed and bullied adolescents. 29921868 2018
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker group BEFREE Human norepinephrine and serotonin transporters (hNET and hSERT) are closely related monoamine transporters (MATs) that regulate neurotransmitter signaling in neurons and are primary targets for a wide range of therapeutic drugs used in the treatment of mood disorders. 30457616 2018
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker group BEFREE Accumulating evidence strongly suggest that impaired glucocorticoid receptor (GR) signaling is involved in stress-related mood disorders, and nominate GR as a potential target for antidepressants (ADs). 28729116 2017
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker group BEFREE Furthermore, escalating rates of obesity, Type 2 diabetes; autoimmune, allergy, addiction and mood disorder-related pathologies, require novel targeted interventions and GR appears a promising pharmacological candidate. 28174120 2017
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation group BEFREE Environmental vulnerability factors such as adverse childhood experiences in interaction with genetic risk variants, e.g., the serotonin transporter gene linked polymorphic region (5-HTTLPR), are assumed to play a role in the development of anxiety and affective disorders. 27145764 2016
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation group BEFREE Further, 2 genetic polymorphisms: the 5-HTTLPR and the brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms were not directly associated with familial risk for affective disorder and did not predict illness onset. 27697135 2016
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation group BEFREE These findings provide novel evidence for both independent and interactive effects of 5-HTTLPR genotype and neuroticism on amygdala communication, which may mediate effects on risk for mood and affective disorders. 26245837 2016
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker group BEFREE 5-HTTLPR modulation of affective disorders varied by gender. 26519640 2016
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 AlteredExpression group BEFREE The glucocorticoid receptor (GR) isoform α plays an important role in the negative feedback regulation of the HPA axis and reduced GRα messenger RNA (mRNA) expression has been shown in mood disorder patients and first-degree relatives compared to healthy individuals with no family history of psychiatric disorders. 26752119 2016
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker group BEFREE Considering the allele-specific sensitivity of SLC6A4 methylation to SLEs, this study may help clarify the role of SLC6A4 in the development of affective disorders. 25849128 2015
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation group BEFREE The role of 5-HTTLPR and 5-HT2C Cys23Ser polymorphisms in the psychopathology of mood disorders and suicide behavior is controversial. 25596490 2015
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker group PSYGENET The role of 5-HTTLPR and 5-HT2C Cys23Ser polymorphisms in the psychopathology of mood disorders and suicide behavior is controversial. 25596490 2015
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation group BEFREE A functional polymorphism (5-HTTLPR) within the serotonin transporter gene (SERT) has been associated with personality dimensions such as neuroticism, with emotional reactivity to negative events, and with an increased risk of affective disorders. 25711941 2015
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation group BEFREE Gene variants of the 5-HT transporter, such as STin2 VNTR (a variable number of tandem repeats in the functional serotonin transporter intron 2) may be associated with mood disorders and TUD. 25451436 2015
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker group PSYGENET Analysis did not show any statistically significant differences in the mean levels of anxiety, and mood disorders in women in relation to genotypes of the 5-HTTLPR (SLC6A4) polymorphism and the 30-bp VNTR polymorphism in the MAO A promoter region. 25547397 2014
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation group BEFREE Although the serotonin transporter length polymorphic region (5-HTTLPR) polymorphism is an extensively-investigated genetic marker of anxiety related personality traits (neuroticism and harm avoidance) and affective disorders, effect sizes in meta-analyses are small, if present at all, and all available primary studies to date lack mandatory statistical power. 24438559 2014
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation group BEFREE Analysis did not show any statistically significant differences in the mean levels of anxiety, and mood disorders in women in relation to genotypes of the 5-HTTLPR (SLC6A4) polymorphism and the 30-bp VNTR polymorphism in the MAO A promoter region. 25547397 2014
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation group BEFREE The alleged association between the serotonin-transporter-linked polymorphic region (5-HTTLPR) and amygdala activation forms a cornerstone of the common view that carrying the short allele of this polymorphism is a potential risk factor for affective disorders. 25253281 2014
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker group BEFREE The FKBP5 gene product modulates glucocorticoid receptor function and has been previously associated with differential hippocampal structure, function, and affect disorder risk. 24253961 2014
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker group PSYGENET Serotonin transporter gene methylation is associated with hippocampal gray matter volume. 24862560 2014
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker group PSYGENET Epigenetic and epistatic interactions between serotonin transporter and brain-derived neurotrophic factor genetic polymorphism: insights in depression. 24972302 2014
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker group PSYGENET Although the serotonin transporter length polymorphic region (5-HTTLPR) polymorphism is an extensively-investigated genetic marker of anxiety related personality traits (neuroticism and harm avoidance) and affective disorders, effect sizes in meta-analyses are small, if present at all, and all available primary studies to date lack mandatory statistical power. 24438559 2014
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker group PSYGENET The FKBP5 gene product modulates glucocorticoid receptor function and has been previously associated with differential hippocampal structure, function, and affect disorder risk. 24253961 2014
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.600 Biomarker group PSYGENET A quantitative-polymerase chain reaction monocyte gene expression analysis was performed with 43 genes previously identified as abnormally regulated in nonpostpartum mood disorder patients including the isoforms of the glucocorticoid receptor. 23270599 2013