Gene: APP ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human High performance plasma amyloid-β biomarkers for Alzheimer's disease. 29420472 2018
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers. 30320580 2018
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease. 28448946 2017
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease. 27117003 2016
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis. 25352456 2015
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human Protective Effect of Notoginsenoside R1 on an APP/PS1 Mouse Model of Alzheimer's Disease by Up-Regulating Insulin Degrading Enzyme and Inhibiting Aβ Accumulation. 25714973 2015
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms. 23827522 2013
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human APP/PS1 transgenic mice treated with aluminum: an update of Alzheimer's disease model. 22507317 2012
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human pH-Dependent Cu(II) coordination to amyloid-β peptide: impact of sequence alterations, including the H6R and D7N familial mutations. 21980910 2011
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human Increasing the predictive accuracy of amyloid-β blood-borne biomarkers in Alzheimer's disease. 21157020 2011
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human Early effects of aluminum chloride on beta-secretase mRNA expression in a neuronal model of beta-amyloid toxicity. 20111991 2010
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human Aβ40 oligomers identified as a potential biomarker for the diagnosis of Alzheimer's disease. 21209907 2010
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. 20157255 2010
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human On the metal ion (Zn(2+), Cu(2+)) coordination with beta-amyloid peptide: DFT computational study. 20640797 2010
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis. 19286555 2009
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer's disease. 19818510 2009
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. 18583042 2008
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease. 16969627 2007
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human "How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the ""LEARn"" model (latent early-life associated regulation) may explain the triggering of AD." 17430250 2007
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions. 17239395 2007
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease. 16651627 2006
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease. 16492752 2006
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human Solution 1H NMR investigation of Zn2+ and Cd2+ binding to amyloid-beta peptide (Abeta) of Alzheimer's disease. 16266835 2006
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease. 16325427 2006
Entrez Id: 351
Gene Symbol: APP
APP 		0.300 Biomarker disease CTD_human Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide. 15591071 2005